GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：phosphine
CAS：7803-51-2
Result：
| ID: | 628 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Category 1 |
|
Danger | H220: Extremely flammable gas |
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381: Eliminate all ignition sources if safe to do so. P403: Store in a well-ventilated place. |
Ignitable when in a mixture of 13% or less by volume in air. UNRTDG Subsidiary risks Class: 2.1 |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not classified | - | - | - | - | UNRTDG Class: 2.2, Subsidiary risks Class: 2.1 |
| 5 | Gases under pressure | Compressed gas or Liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | According to its physical state when packed, classified in; Compressed gas: entirely gaseous at -50degC or, Liquefied gas: partially liquid at temperatures above -50degC (a critical temp. >-50degC) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Not classified | - | - | - | - | UNRTDG Class: 2.3, Subsidiary risks Class: 2.1 |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Dermal） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Gases） | Category 1 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
It was considered as Category 1 based on rat LC50 (4 hours) level: 11ppm (EHC 73, 1988, ACGIH 7th, 2001, industrial hygene academic society recommentation, 1998). |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | We found the negative results (IRIS and 2006, Japan Society for Occupational Health Recommendation of Occupational Exposure Limits, 1998) by the dominant lethality tests using the mouse, which were in vivo over generation mutagenicity tests using the germ cells, and found the negative results (NTP DB, 2006, Japan Society for Occupational Health Recommendation of Occupational Exposure Limits, 1998) by the micronucleus tests which used the rat or the mouse marrow cells and peripheral blood, which were the in vivo mutagenicity tests using the somatic cells. Therefore we classified it as Out Of Category. |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Since it was classified into D according to EPA in 1996 (IRIS, 2006), it carried out the outside of Category. |
| 7 | Reproductive toxicity | Not classified | - | - | - | - | Based on description that specific reproductive toxicity was not observed at least 5 ppm (about 1/2 of LD50 value) considered to be the highest dosage in which a repeated administration is possible without mortality in a maternal animals in an inhalation atmospheric exposure test to the pregnancy rat (IRIS (2006)), it was considered as on the outside of Categry. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, respiratory system, liver, gastrointestinal tract, cardiovascular system) |
|
Danger | H370: Causes damage to organs (nervous system, respiratory system, liver, gastrointestinal tract, cardiovascular system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the descriptions that in the inhalation exposure test using rat or mouse, strong airway irritation and effects on nerve systems such as lying in prone positions and tremors were observed within the guidance value range of Category 1(ACGIH (7th, 2001) and Japan Society for Occupational Health Recommendation of Occupational Exposure Limits (1998)), that effects on nerve systems, dijestive canals and respiratory systems are identified in the acute human exposure (EHC 73 (1988) and IRIS(2006)), and that pulmonary edema, jundice, hepatomegaly, abnormal sensation, shivering, localized myocardial necrosis, nausea, vomiting and diarrhea were identified in the human evidence of exposure including fatal cases (IRIS (2006), Japan Society for Occupational Health Recommendation of Occupational Exposure Limits(1998)). So it was set as Category 1 (nerve systems, respiratory systems, liver, dijestive canals, cardiovascular systems) |
| 9 | Specific target organ toxicity - Repeated exposure | Not classified | - | - | - | - | Based on the description that the serious toxic effect by the highest dosage within a repeatedable doses was not acknowledged and no acknowledgement of death in the inhalation exposure test using a rat, a mouse or a guinea pig of EHC 73 (1988), IRIS (2006) and industrial hygiene academic society advice (1998), and the discription that in ocupational evidence of exposure, symptom was acknowledged for every exposure, but there is no a chronic effects in ACGIH (7th, 2001) and industrial hygiene academic society advice (1998), so it was classified to as the outside of Category. |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Gas (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |