GHS Classification Result

Chemical Name：Dimethyl sulfate
CAS：77-78-1

Result：
ID: 627
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: >60degC and <=93degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 188degC (Weiss, 2nd, 1986, p400)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 6.1
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not classified - - - - UNRTDG Class: 6.1
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Calculated based on rat oral LD50 values = 440mg/kg (CERI Hazard Data (1999), EHC 48 (1985), EU-RAR (2002)), 1450mg/kg (CERI Hazard Data (1999)), 205mg/kg (EHC 48 (1985), EU-RAR (2002)), and 106mg/kg (EU-RAR (2002)). Since the calculated values was 188.1mg/kg, it was set as Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Judging it as vapor from its vapor pressure. Calculated based on rat inhalation LC50 (1 hour) = 64ppm (4 hour equivalent: 0.168mg/L) (CERI Hazard Data (1999), EHC 48 (1985), DFGOT vol4 (1992)), 0.335mg/L (4 hour equivalent: 0.168mg/L) (EU-RAR (2002)), LC50 (4 hours) = 9ppm (equivalent 0.05mg/L) (CERI Hazard Data (1999)), 0.045mg/L (EHC 48 (1985), EU-RAR (2002)) and 0.168mg/L (EU-RAR (2002)). Calculated value is 0.0748mg/L, and it was classified as Category 1 based on the equivalent of this value at 14ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on descriptions that it has strong irritative and corrosive effect on human skin (CERI Hazard Data (1999)) and that necrosis was seen in rabbit skin application test (CERI Hazard Data (1999), EU-RAR (2002)), it was classified as Category 1A-1C.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		From description that it had strong stimuli and corrosive effect to an eye and the skin in humans (CERI Hazard Data(1999)), and from description that severe irritation was acknowledged by apply to the eye of the rabbit (CERI Hazard Data (1999) and EU-RAR (2002)), it was set as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the dominant lethality test using the mouse it gave negative (EHC 48 (1985), EU-RAR (2002) and CERI Hazard Data (1999)), however, it gave positive in the chromosomal aberration test (IARC 71 (1999) EHC 48 (1985) and CERI Hazard Data (1999)) using myeloid cells of rat and mouse, positive in the mouse spot test (EHC 48 (1985), CERI Hazard Data (1999)) and negative (EU-RAR (2002)). And it gave positive in the chromosomal aberration test (EHC 48 (1985), CERI Hazard Data (1999)) using the rat and the mouse peripheral lymphocytes, and positive in the chromosomal aberration test (IARC 71 (1999)) using the fetal mouse, and there was no report of the in vivo genotoxicity examination with the productive cells. So we classified it as Category 2.
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is classified into A3 according to ACGIH (7th, 2001) and is classified into B-2 according to EPA (2005). And it is classified into 2A according to IARC 71 (1999), into 2 according to EU (2005), and into 2A according to Japan Society for Occupational Health (2005). Therefore, it was set as category1B.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since although fetotoxicity was clearly observed at hygh dose exposure test in inhalation exposure tests to rats and mice in all pregnant period or 1-13 days of pregnant (EHC 48 (1985), ACGIH (7th, 2001) and the CERI hazard data collection(1999)), details of the test method and effects on mother animals are not clear, therefore, it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, central nervous system, liver, kidney, heart), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (respiratory system, central nervous system, liver, kidney, heart)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		According to the descriptions that pulmonary edemas and respiratory disorders are identified in human exposure cases (CERI Hazard Data (1999), EHC 48 (1985), ACGIH (7th, 2001), DFGOT vol4 (1992) and EU-RAR (2002)), that effects on the central nerve systems such as convulsion, coma and paralysis are observed in human exposure cases (CERI Hazard Data(1999), EHC 48 (1985), ACGIH (7th, 2001)), and that kidney or liver tardive or cardiac delayed disorder were observed in human exposure cases (EHC 48 (1985) and ACGIH (7th, 2001)). So it was judged that the target organs were respirstory systems, central nerve systems, kidney, liver and cardiac, and they were all set as Category 1. In addition, such irritant as inflammation of the upper respiratory tract etc., has been identified in low concentrations, too. It was set as Category 3 (respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Category 2 (lung) Warning H373: May cause damage to organs through prolonged or repeated exposure (lung) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since there was description in the ICSC (J)(1995) that lungs may be risked by effect of repeated exposure, it was judged that lungs were target organ, and classified to as Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96-hour LC50=7.5mg/L of fishes (Bluegill), and others (EU-RAR, 2002).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (28-day decomposition rate of the OECD test guideline 301A: 87% (EU-RAR, 2002)), and less bio-accumulative (log Kow=0.16 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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