GHS Classification Result

Chemical Name：iodomethane
CAS：74-88-4

Result：
ID: 622
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - There is no flash point (Lange (14th, 1992) p.1.232) or it is nonflammable. (ICSC(J) (2004) and Hommmel (1991) Card No.942)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Non-combustible (ICSC (J), 2004, Hommel, 1991 Card No.942)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC (J), 2004; Hommel, 1991, Card No.942)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG No. 2644, Class: 6.1

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		SPECIES: Rat (male) ENDPOINT: LD50 VALUE: 51 mg/kg REFERENCE SOURCE: Agricultural Chemicals abstracts
1 Acute toxicity （Dermal） Not classified - - - - since rabbit LD50 value: >2000mg/kg and there was no death at 2000mg/kg or less (Agricultural-Chemicals abstracts), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rat LC50 (4 hours) value: 691ppm (equivalent of 4 mg/L) (Agricultural-Chemicals abstracts), and 691ppm indicates steam with almost no mist from vapor pressure, it was classified as Category 3 by the ppm concentration standard.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Since the moderate irritation was observed with 4 hour exposure in the skin irritation test on rabbits (Agricultural-Chemicals abstracts), it was classified as Category 2.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since very strong stimulativeness was indicated in the eye irritation test result using a rabbit and it did not recover completely during the observation period for 21 days (Agricultural-Chemicals abstracts), it was set as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Since the positive rate was less than 30% in Maximization test using the guinea pigs (Agricultural Chemicals abstracts), it was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - Since we found a negative result in the micronucleus test which used the mouse red corpuscles, which was the in vivo mutagenicity test using the somatic cells (Agrichemical Abstracts), we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into the group 3 (IARC 71, 1999) according to IARC, it carried out the outside of Category.
7 Reproductive toxicity Not classified - - - - Since there is no obvious reproductive toxicity in the dose causing general toxicity to parent animals in inhalation exposure to pregnant rabbit and in the rat inhalation exposure reproduction study (Agricultural-Chemicals abstracts), it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the acute neurotoxicity test by inhalation exposures with rats, mild and transcient effects on nerve systems and symptoms suggesting airway irritation such as shallow respiration, droopy eyelids, hyper salivation, gasping, hunchback position, gait disorder, slight incoordination of air recovery reflection, lack of response to fright reactions, decrease of Lotta load movements coordination, decrease of movements and locomotor activities etc. were observed (Agricultural chemical abstracts). So it was set as Category 3 (airway irritation, anesthetic action).
9 Specific target organ toxicity - Repeated exposure Category 2 (thyroid, respiratory system) Warning H373: May cause damage to organs through prolonged or repeated exposure (thyroid, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to Category 2 (thyroid gland, respiratory organs) since retention increases of thyroidal follicular clloid and involved thinning of the follicular ephitheliocyte in the oral study using mice, colloid depletion in thyroid gland and hypertrophy follicle cell in the oral study using dogs, and follicular cell hyperplasia and cytoplasmic vacuolization of follicular cell in thyroidal folliclar cell and olfactory-epithelium degeneration of nose in the inhalation exposure test using rats were acknowledged respectively with the given dose of the guidance value range of Category 2 (Agricultural Chemicals abstracts).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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