GHS Classification Result

Chemical Name：5-methyl-1,2,4-triazolo[3,4-b]benzo-1,3-thiazole
CAS：41814-78-2

Result：
ID: 619
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Containing no oxygen , chlorine and fluorine.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Calculated based on rat (female) LD50 values: 223mg/kg, 289.7mg/kg, and 301.9mg/kg (Agricultural-Chemicals abstracts). The calculation level was 231.3mg/kg, it was set as Category 3.
1 Acute toxicity （Dermal） Not classified - - - - Based on rat LD50 value: >5000mg/kg (Agricultural-Chemicals abstracts), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - An original object rat LC50 (1 hour) value is >146mg/m3 (4-hour equivalent >0.0365mg/L), 75% wettable powders rat LC50 (1 hour) value is >2.33mg/L (4-hour equivalent >0.583mg/L)(Agricultural-Chemicals abstracts). But the category could not be specified only by these data. Therefore, it cannot be classifed since data is insufficient.
2 Skin corrosion/irritation Not classified - - - - Since change that matches for slight stimulation criteria was not observed with exposure for 24 hours in the skin irritation test on rabbits (Agricultural-Chemicals abstracts), it was classified as out of Category.
3 Serious eye damage/eye irritation Not classified - - - - Since change of the eye which was adapted to criteria for assessments of irritation in eye irritation tests of rabbits was not admitted (Agricultural-Chemicals abstracts), it was set as the outside of Category.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - Since the skin sensitization was negative in Buehler test using the guinea pigs (Agricultural Chemicals abstracts), it was put outside of the Category.
5 Germ cell mutagenicity Not classified - - - - Since there was a negative result in the micronucleus test which used the mouse marrow cells, which was the in vivo mutagenicity test using the somatic cells (Agrichemical Abstracts), we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - Neither of the organizations had categorized about carcinogenic. But oncogenicity was not acknowledged (Agricultural-Chemicals abstracts) in the chronic toxicity/carcinogenic test using rats and mice. So it carried out the outside of category.
7 Reproductive toxicity Classification not possible - - - - Since although there is no effect on reprofuctive potential in reproductive test of rat and there is no teratogenicity in teratogenicity test on rat and rabbit (Agricultural-Chemicals abstracts) and there is no the general toxicity to parent animals in the all of the tests, it is considered as cannot be classified.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although toxic symptoms are observed by the oral medication test using rats and mice(Agricultural chemical abstracts), since the dose volume was unknown, it was decided that it could not be classified due to the insufficiency of data.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to as Category 2 (liver) since the effects on liver such as hypertrophy of hepatic cells and lobulic peripheral hepatocyte eosinophilic degeneration, etc. is acknowledged with the given dose of the guidance value range of Category 2 in the long-term oral test using rats and mice (agricultural- chemicals abstracts).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from ErC50=16mg/L of algae (Green algae) (Agricultural Chemical Registration Data, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Classified into Category 3, since acute toxicity was Category 3 and supposed not rapidly degrading (BIOWIN), though supposed less bio-accumulative (log Kow=1.7(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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