GHS Classification Result

Chemical Name：2-Butanone
CAS：78-93-3

Result：
ID: 618
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: <23degC, Boiling point: >35degC, UNRTDG Class: 3, PG II
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 505degC (ICSC (J), 1998)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Calculated based on rat oral LD50 value = 5520mg/kg (EHC 143 (1992), ACGIH (7th, 2001), PATTY (4th, 1994), IRIS (2003), ATSDR (1992)), 2737mg/kg (PATTY (4th 1994), IRIS (2003), ATSDR (1992)), 2483mg/kg (PATTY (4th, 1994)), and 2884mg/kg (PATTY (4th, 1994)). But the calculation value was lower than lowest value of these data, lowest value was adopted, and it was set as Category 5.
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbit dermal LD50 5000mg/kg (PATTY (4th, 1994)), >8000mg/kg (EHC 143 (1992), DFGOTvol.12 (1999), PATTY (4th, 1994), ATSDR (1992)), and 13000mg/kg (PATTY (4th, 1994)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. It was classified as Category 5 based on rat inhalation LC50 (4 hours) value = 11700ppm (EHC 143 (1992), PATTY (4th, 1994), IRIS (2003), ATSDR (1992)).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		There is description that when exposed to human skin, irritation was not observed (EHC 143 (1992), DFGOTvol.12 (1999), PATTY (4th, 1994), and ATSDR (1992)). But based on the description that mild to moderate irritation was observed in the skin application examination on rabbits (EHC 143 (1992), DFGOTvol.12 (1999), PATTY (4th, 1994), and ATSDR (1992)), it was classified as Category 2.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There is description that irritation was seen in the eye in humans evidence of exposure to vapor (ACGIH and (7th, 2001), DFGOTvol.12 (1999), PATTY (4th, 1994), and IRIS (2003)). And the average value of the mark in 24 hours was corneal cloudings 2.5 and the conjunctival redness 2 in the eye irritation examination using a rabbit, but it had recovered mostly within seven days (ECETOC TR48 (1992)). So it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there are descriptions of one case in which the contact dermatitis was seen, based on the same former literature(EHC 143 (1992)), DFGOTvol.12 (1999), PATTY (4th, 1994), and ATSDR (1992), there are no other case reports, and since there is a negative statement by Mouse Ear Swelling Test (DFGOTvol.12 (1999) and PATTY (4th, 1994)), it was decided that it could not be classified due to lack of sufficient data.
5 Germ cell mutagenicity Not classified - - - - Since there were the negative results by the micronucleus tests which used mammalian erythrocytes (EHC 143 (1992), DFGOTvol.12 (1999), PATTY (4th, 1994), IRIS (2003), ATSDR (1992)), we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - Since it was classified into I (inadequate) according to EPA, it carried out the outside of Category.
7 Reproductive toxicity Not classified - - - - There are descriptions that fetal malformations were observed in teratogenicity studies of inhalation exposures in rats (EHC 143 (1992), DFGOTvol.12 (1999), PATTY (4th, 1994), IRIS (2003), and ATSDR (1992)). In a retest, however, malformations are not observed, although delayed ossification and mutations were observed (EHC 143 (1992), ACGIH (7th, 2001), DFGOTvol.12 (1999), PATTY (4th, 1994), IRIS (2003) and ATSDR (1992)). Furthermore, malformation is not observed, although lower weight levels of offsprings and mutations were also observed in teratogenicity studies of inhalation exposure to mice (EHC 143 (1992), ACGIH (7th, 2001), DFGOTvol.12 (1999), PATTY (4th, 1994), IRIS (2003) and ATSDR (1992)). Therefore, all were judged to be minimum influence and were placed out of classification.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 2 (kidney), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (central nervous system)
H371: May cause damage to organs (kidney)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		There are descriptions that effects on the central nerve system were not observed in the inhalation exposure test by humans (EHC 143 (1992), DFGOTvol.12 (1999), IRIS (2003), and ATSDR (1992)), and that there was no statistically significant difference against contrast groups in the result of the time estimation test (EHC 143 (1992) and PATTY (4th, 1994)). On the other hand, since effects on the central nerve systems in the inhalation exposure test of the rat or the mouse were identified in comparatively low concentrations (EHC 143 (1992), PATTY (4th, 1994) and IRIS (2003)), the target organ was judged to be the central nerve system and it was set as Category 1. Moreover, based on the description that effects were observed in kidney by a moderate dosage of the oral administration to rats (DFGOTvol.12 (1999), IRIS (2003), and ATSDR (1992)), kidney was also judged to be the target organ and was set as Category 2. Furthermore, it was set as Category 3 based on the description that respiratory irritation was observed by the human evidence of inhalation exposure (ACGIH (7th, 2001), DFGOTvol.12 (1999), PATTY (4th, 1994), IRIS (2003), and ATSDR (1992)).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, peripheral nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, peripheral nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified all to Category 1considering target organ a central nervous systems and the peripheral nervous system, according to the description that the sensory paralysis of hand and arm was seen in the case of human occupation exposure(EHC 143 (1992), DFGOTvol.12 (1999) and IRIS (2003)), the description suggesting the central nervous systems disorders in the case of occupation exposure (DFGOTvol.12 (1999) and IRIS (2003)), and the description about three cases in which the effects on the central nervous systems were seen (IRIS (2003)).
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 2 because of being a primary normal alcohol composed of carbon atoms (3<=n>=13) and containing an isobutyl alcohol and ketone composed of carbon atoms (n>=13).

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50>100mg/L of fishes (Oryzias latipes) (MOE eco-toxicity tests of chemicals, 1996).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility =2.23*105mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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