GHS Classification Result

Chemical Name:Methanamine
CAS:74-89-5

Result:
ID: 617
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Category 1 Danger H220: Extremely flammable gas P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381: Eliminate all ignition sources if safe to do so.
P403: Store in a well-ventilated place.
Flammable range with air is 4.9-20.7 vol%.
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not classified - - - - Flammable gas
5 Gases under pressure Low pressure liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Critical temp: 156.9degC
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gas substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Calculated based on rat LD50: 100 to 200 mg/kg (ACGIH (2001) and DFGOT (1996)) and 698mg/kg (DFGOT (1996)). Since the calculated values was less than the lowest value, it was set as Category 3 based on 100mg/kg of the lowest value.
1 Acute toxicity (Dermal) Classification not possible - - - - The data of the guinea pigs were in PATTY (1994). But LD50 was not clear, it could not be classified due to the insufficient data.
1 Acute toxicity (Inhalation: Gases) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Statistics calculation was done based on rat LC50 (4 hours): 4400ml/m3 and 6400 - 9100ml/m3 (all are DFGOT Vol.7 (1996)). Since the calculation value of 4400ml/m3 (4400ppm) was the same as the lowest value, it was considered as Category 4.
1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
There was no skin irritation test data of this product (gas). But based on the description that 40% aqueous solution caused necrosis on skin of rabbits (PATTY, 4th 1994), it was judged to have skin corrosivenesses, and it was classified as Category 1A-1C. Since detailed data was unknown, sub-categorization was not available. [Display] It is more desirable to be classified as 1A from a viewpoint of safety, when it is necessary to sub-categorize.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
There is no data in eye irritation tests by this product (gas). But there is description that 40% solution has strong stimulativeness in the eye of a rabbit (ACGIH, 7th, 2001) and the lesional of a corneal (PATTY, 4th, 1994), it was set to Category 1.
4 Respiratory sensitization Classification not possible - - - - Although the allergenic or irritation data of bronchitis can be found on unpublished cases (ACGIH, 7th, 2001), since there is no case report in well known literature, it was decided that it could not be classified due to lack of sufficient.data.
4 Skin sensitization Classification not possible - - - - No data
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
We classified it as Category 1B. Based on the description (RTECS (2005)) that there was a positive result in the dominant lethality examination by rat inhalation exposure examination.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - There is a statement that post-implantation fetal death increases depending on a dose in an inhalation exposure test of pregnant rats (DFGOT (1996)). However, it is indicated that evaluation is impossible, since details are not shown in the source material in the reference. On the other hand, although there is a report that reproductive toxicity tests in murine intraperitoneal administration did not show any effects (IUCLID (2000)), it will not negate the rat data of Priolity1. Therefore, since data was insufficient, it was considered unable to be classified.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although it is a Priolity 2 information, since there is a description that it has respiratory irritation against mucous membranes and may cause lung edemas at high exposure leves (HSFS (2004) and SITTIG (2002)), and it is classified as a substance which has an irritant action against the respiratory systems in the EU classification of dangerous sbstances as well. So it was set as Category 3 (respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory system, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (respiratory system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
The details are unknown, although the deviation enzyme in the blood including a nervous system, liver, and an immunology parameter and the morphological defect of organs, etc. in the nasal region exposure test for rats in DFGOT (1994) are reported. On the other hand, it was classified to Category 2 (respiratory systems, liver), since it is reported bronchitis and it has a potential to effect on liver by higher concentration exposures in HSFS (2004) and SITTIG (2002).
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - it carried out the outside of Category from 48-hour EC50=163000microg/L of Crustacea (Daphnia magna), and others(AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (water solubility=1.08*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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