GHS Classification Result

Chemical Name：Methanol
CAS：67-56-1

Result：
ID: 616
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: <23degC, Boiling point: >35degC, UNRTDG Class: 3, PG II
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Flash point: 385degC (Solvent Pocket Book , 1994 p391-401)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG Class: 3
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 3

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Calculation was done based on rat oral LD50 value = 6200mg/kg (EHC 196 (1997), ACGIH (7th, 2001), DFGOT vol.16 (2001), PATTY (4th, 1994)), 9100mg/kg (EHC 196 (1997), PATTY (4th, 1994)), 12900mg/kg (EHC 196 (1997), DFGOT vol.16 (2001), PATTY (4th, 1994)), and 13000mg/kg (EHC 196 (1997), ACGIH (7th, 2001), PATTY (4th, 1994)). The calculation value was 7939mg/kg, and it was judged to be the outside of Category from the result of the animal experiments. On the other hand, there is description that the toxicity of methanol appears highly in primates compared with rodent (EHC 196 (1997)). And the dose leading to death in an about half in humans is 1400mg/kg (DFGOT vol.16 (2001)), it was set as Category 5.
1 Acute toxicity （Dermal） Not classified - - - - Based on rabbits percutaneous LD50 value = 15800mg/kg (DFGOT vol.16 (2001), PATTY (4th, 1994)), it was set as the outside of Category.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Not classified - - - - Based on rat inhalation LC50 (8 hours) value = 22500ppm (DFGOT vol.16 (2001), assumed to be vapor from vapor pressure, it was classified as out of Category.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - While there is description that the moderate irritation was seen after 24-hour exposure with the degreasing action in rabbit test (DFGOT vol.16 (2001)), there is description that irritation was not seen in another test which applicated it on rabbit for 20 hours obstructions, and since the test data based on exposure of less than 4 hours was not obtained, it was not able to classify.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is description that mild or moderate eye irritation was admitted by the test using the rabbit (EHC 196 (1997), DFGOT vol.16 (2001), and PATTY (4th, 1994)). But there is no clear description about reparable, and the obstacle of a cornea and strong conjunctiva dropsy were transiently admitted in human (DFGOT vol.16 (2001)). So it was set as Category 2A-2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there is a description (PATTY (4th, 1994)) which cited two or more articles reporting allergic contact dermatitis in human skin evidence of exposure, there is no description on the concrete cases. On the other hand, there are descriptions (EHC 196 (1997) and DFGOT vol.16 (2001)) that sensitization was not identified in the Magnusson-Kligman maximization test using the guinea pigs. Since data was insufficient for judging the existence of skin sensitization from these information, it could not be classified.
5 Germ cell mutagenicity Not classified - - - - Since there were the negative results (EHC 196 (1997), DFGOT vol.16 (2001), PATTY (4th, 1994)) by the micronucleus test which used mouse erythrocytes, we classified it as Out Of Category.
6 Carcinogenicity Classification not possible - - - - Since it is not evaluated in the institution indicated in the technical indicator, it cannot classify. In addition, carcinogenic is not admitted in inhalation exposure tests using rats and mice.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since although there are descriptions that increase in fetal malformation or fetal death was observed in an oral and inhalation exposure test using pregnant rats and mice (EHC 196 (1997), ACGIH (7th, 2001), DFGOT vol.16 (2001) and PATTY (4th, 1994)) and there is no reliable data of human examples of exposures, it was classified into class 1B. There are descriptions that decrease in testosterone concentration or testicular degeneration was observed in male rats (EHC 196 (1997), DFGOT vol.16 (2001), and PATTY (4th, 1994)). On the contrary, however, some descriptions of any effects on reproductive tract of males were not observed, and so effects on the reproductive ability of males are not clear.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, visual organs, systemic toxicity), Category 3 (respiratory tract irritation, narcotic effects) Danger
Warning 		H370: Causes damage to organs (central nervous system, visual organs, systemic toxicity)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		According to the descriptions that central nervous system depression and visual organ disorder are observed by acute oral or inhalation exposure by humans (EHC 196 (1997), ACGIH (7th, 2001), DFGOT vol.16 (2001), PATTY (4th, 1994) and Japan Society for Occupational Health Recommendations of Occupational Exposure Limits (1993)), and that metabolic acidosis is observed in human evidence of exposure (ACGIH (7th, 2001) and DFGOT vol.16 (2001)), their targets were judged to be the central nervous system, visual organs, and systemic toxicity, and they were all set as Category 1. Moreover, based on the descriptions that respiratory irritation was observed by the repeated inhalation exposure tests with rats (EHC 196 (1997) and PATTY (4th, 1994)) and that mucosal irritation is observed in humans (Japan Society for Occupational Health Recommendation of Occupational Exposure Limits), and since the anesthetic actions were identified by the rat, mouse, Macaca mulatta, etc., (EHC 196 (1997) and PATTY (4th, 1994)). So it was judged that there were respiratory irritation and anesthetic actions, and they were all set as Category 3.
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, visual organs) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, visual organs) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was set all to Category 1because target organs are a central nervous system and an optic organ according to the description of the central nervous system depression and the optic organ's disorders were seen in a case of long-term exposure in humans (EHC 196 (1997), ACGIH (7th, 2001), and DFGOT vol.16 (2001)).
10 Aspiration hazard Classification not possible - - - - Insufficient data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 24-hour LC50=900.73mg/L of Crustacea (Brine shrimp) (EHC196, 1998).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (water solubility=1.00*106mg/L(PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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