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GHS Classification Result

Chemical Name：aldrin
CAS：309-00-2

Result：


ID:	614
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	-	-	-	-	Non-combustible (ICSC (J) (1998))
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Non-combustible (ICSC (J), 1998)
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Not combustible (ICSC(J) (1998))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Organic compounds containing chlorine (but not oxygen and fluorine) and the chlorine is chemically bonded only to carbon and hydrogen (but not to other elements).
15	Organic peroxides	Not applicable	-	-	-	-	Containing no -0-0- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Although there is information that it corrodes metal by hydrochloric acid forms in long-term storages (HSDB (Access on Jan .2006)), test methods suitable for a solids material are not established.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Calculated based on rat LD50 values: about 67mg/kg, 45.9mg/kg and 50mg/kg (PATTY 4th, 1994), 38 to 67 mg/kg (EHC 91, 1989), 39mg/kg (MOE Risk Assessment the 1st volume, 2002), about 60mg/kg (ACGIH 7th, 2001), 39mg/kg, 63.5mg/kg and 48.3mg/kg (ATSDR, 2002). Since the calculated values was 45.7mg/kg, it was set as Category 2.
1	Acute toxicity （Dermal）	Category 2		Danger	H310: Fatal in contact with skin	P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 2 based on rat LD50 value: 98mg/kg (EHC 91, 1989, ATSDR, 2002, MOE Risk Assessment, the 1st volume, 2002) and rabbit LD50 value: about 150mg/kg (PATTY 4th, 1994, EHC 91, 1989).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 1		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	From description that nine among ten rats died from 1-hour exposure of 0.108mg/L (4-hour equivalent 0.027mg/L) in the vapors and particles inhalation exposure tests (ATSDR (2002)), it was set as Category 1.
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	It was classified as Category 3 from description that very slight erythema was observed with skin contacts on humans (PATTY (4th, 1994)).
3	Serious eye damage/eye irritation	-	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	It was set as Category 2B from description that mild irritation was admitted in the test which was applied the 48% emulsion to the eye of the rabbit of EHC 91 (1989) and ATSDR (2002).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data
4	Skin sensitization	-	-	-	-	-	From a description that a positive reaction was identified by three samples among 20 (15% positivity rate) in the maximization test using the guinea pigs on the 48% emulsion of EHC 91 (1989), it was judged that skin sensitization was negative, and it was put outside of the Category.
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	We found the negative results in the dominant lethality tests using the mouse, which were the in vivo over generation mutagenicity tests using the germ cells (EHC 91 (1989), ATSDR (2002) and IARC Suppl.6 (1987)), found a positive result in the chromosomal aberration test using the rat and mouse marrow cells, which was the in vivo mutagenicity test using the somatic cells (IARC Suppl.7, 1987), and found no positive result for the in vivo genotoxicity study using the germ cells. Therefore we classified it as Category 2.
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Classified into the group 3 according to IARC (IARC Suppl.7, 1987). But it was categorized into A3 by ACGIH (ACGIH 7th, 2001), into B2 by EPA in 1993 (IRIS, 2006), and into category 3 by EU (EU-Annex I, 2006). And it was set as category 2 according to ACGIH which is latest assessment document.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	There is no description about the general toxicity to parent animals. Since there are descriptions that fetal mortalities and increased malformationl incidence were observed in oral administration examination during the fetal organogenetic period or in a multi-generation breeding examination of mouse or hamster (ACGIH (7th, 2001), PATTY (4th, 1994), EHC 91 (1989) and ATSDR (2002)), it was classified into Category 2.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	According to the descriptions that the influence on the nervous systems such as spasm etc. was identified in the large intake cases (ACGIH (7th, 2001), PATTY (4th, 1994), and ATSDR (2002)), and that shivering and spasm were identified by the dose of guidance value range of Category 1 in the oral medication test using the rat (PATTY (4th, 1994)), it was set as Category 1(nerve systems).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, liver, kidney)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver, kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It was classified to as Category 1 (liver, kidney, nervous system) according to the description that the effects on the fatty degeneration and necrosis of hepatocyte, the effects on the kidney as renal tubular degeneration, and convulsion were acknowledged with the given dose of the guidance value range of Category 1, in the long-term oral administration test using rats, mice and dogs of ACGIH (7th, 2001), PATTY (4th, 1994), EHC 91 (1989), ATSDR (2002), IRIS (2006), and NTP TR21 (1978), and the description that convulsion was acknowledged in human as a case of occupational exposure in EHC 91 (1989) and ATSDR (2002).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96-hour LC50=2.2microg/L of fishes (Rainbow trout) (EHC91, 1989).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=20000 (existing chemical substances safety inspections data)).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）