GHS Classification Result

Chemical Name：Hexachlorocyclopentadiene
CAS：77-47-4

Result：
ID: 613
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Non-combustible (Hommel, 1991, Card No.1075).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Non-combustible (Hommel, 1991 Card No.1075 ; etc.)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (Hommel, 1991, Card No.1075; etc.)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Although it is classified into the class 6.1 in UNRTDG, there is also information that it corrodes various metals under the presence of moisture content. (HSDB (2005))

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Calculated based on rat LD50 values: 510mg/kg, 926mg/kg, 651mg/kg, and 315mg/kg (EHC 120, 1991), 505mg/kg and 530mg/kg (IRIS, 2001), 584mg/kg and 471mg/kg (ATSDR, 1999). Since the calculated values was 459mg/kg, it was set as Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - If the lower value is adopted based on rabbit LD50 value: 780mg/kg and <200mg/kg (EHC 120, 1991), Category was not able to be specificked. So it was determined that it cannot be classified.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on rat LC50 (4 hours) value: 0.0181mg/L (EHC 120, 1991, IRIS, 2001, ATSDR, 1999), vapor pressure of 0.0181mg/L (1.6 ppm) was judged to be steam with almost no mist. It was classified as Category 1 by the ppm concentration standard.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was classified as Category 2 from descriptions that moderate to severe irritation were observed in rabbit skin application test (EHC 120 (1991)) and skin irritation on humans was observed with exposure (IRIS (2001), and ATSDR (1999)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		It was set as Category 2A from description that severe irritation was admitted in the test applied to the eye of the rabbit of EHC 120 (1991) and ATSDR (1999).
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the description that in a skin sensitivity test using the guinea pigs of EHC 120 (1991) the positive rate was 100% and it was conclude to be a skin sensitizing substance, it was referred to as Category 1.
5 Germ cell mutagenicity Not classified - - - - It gave the negative results by the dominant lethality test using the mouse, which was an in vivo over generation mutagenicity test using the germ cells (EHC 120, 1991, ATSDR, 1999, NTP TR437, 1994), and it gave the negative results (IRIS, 2001, ATSDR, 1999, NTP DB, 2005) by the micronucleus test using the mouse erythrocytes, which were the in vivo mutagenicity tests using the somatic cells. So we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - It was classified into E in 1986 and classified into NL (all are IRIS and 2001) according to ACGIH by A4 (ACGIH 7th, 2001) and EPA in 1996. So it carried out the outside of Category.
7 Reproductive toxicity Not classified - - - - Based on description of no serious reproductive toxicity in maternal rabbit oral administration during pregnancy at dose of occuring general toxicity to maternal animals, and of no general toxicity and reproductive toxicity in oral administration to pregnant rat and mouce (EHC 120 (1991), IRIS (2001), NTP TR437 (1994)), it is considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system), Category 2 (liver, kidney) Danger
Warning 		H370: Causes damage to organs (respiratory system)
H371: May cause damage to organs (liver, kidney) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. 		According to the descriptions that severe respiratory irritation was identified in the human evidence of exposure (EHC 120 (1991), IRIS (2001), ACGIH (7th, 2001), NTP TR437 (1994), ATSDR (1999)), and that the influence such as pulmonary edemas etc. on the respiratory tracts was identified within the guidance value range of Category 1 in the inhalation exposure test using the rat (IRIS (2001) and ATSDR (1999)). So it was set as Category 1 (respiratory tracts). Moreover, it was set as Category 2 (liver, kidney) based on the description that the effects on the liver and kidney were identified with the given dose of guidance value range of Category 2 in the oral medication test using rats and rabbits (ATSDR (1999)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system), Category 2 (kidney) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (respiratory system)
H373: May cause damage to organs through prolonged or repeated exposure (kidney) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to as Category 1 (respiratory organs) and 2 (renal) according to the description that the effects on the respiratory tract were acknowledged by the concentration of the guidance value range of Cattegory 1 in the 13-week inhalation exposure test using rats and mise of EHC 120 (1991), NTP TR437 (1994), IRIS (2001), ATSDR (1999), and the description that the effects on kidney were acknowledged with the given dose of the guidance value range of Category 2 in the oral study using rats and mise.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.007mg/L of fishes (Fathead minnows) (EHC120, 1991).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=5.04 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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