GHS Classification Result

Chemical Name:endrin
CAS:72-20-8

Result:
ID: 611
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J) (2000), Hommel(1991) Card No.269)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 2000; Hommel, 1991, Card No.269)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC (J), 2000; Hommel, 1991, Card No.269)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. Slightly corrosive to metals. (HSDB, Access on Jan. 2006)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Calculated based on rat LD50 values: 3mg/kg (MOE Risk Assessment the 1st volume, 2002), 5.3mg/kg (ACGIH 7th, 2001), 13mg/kg (PATTY 4th, 1994), 9, 4, and 27mg/kg (EHC 130, 1992), 16.8, 7.3, 40, 7.5, and 5.3mg/kg (EHC 130, 1992, ATSDR, 1996). Since the calculated values was 6.54mg/kg, it was set as Category 2.
1 Acute toxicity (Dermal) Category 1 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Calculated based on rat LD50 value: 18mg/kg (MOE Risk Assessment the 1st volume, 2002), 15mg/kg (ACGIH 7th, 2001, ATSDR, 1996, EHC 130, 1992), 5mg/kg (DFGOT vol.18, 2002, EHC 130, 1992) and 12.5mg/kg (EHC 130, 1992). Since the calculated values was 8.07mg/kg, it was set as Category 1.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - There is description that 3-5 among 10 examples died from the mists and dust concentration of 2mg/L in the test which carried out exposure to the rat for 1 hour (4-hour equivalent 0.5 mg/L) (EHC 130 (1992), DFGOT (vol.18, 2002)). But there is no data of LC50 value. Therefore, it cannot be classified since the category cannot to be specified.
2 Skin corrosion/irritation Not classified - - - - From descriptions that 24 hour exposure test on rabbits show no skin effects (EHC 130 (1992), DFGOT (vol.18, 2002), and ATSDR (1996)), it was judged that there was no skin irritation and was classified as out of Category.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there was description that skin sensitization was not identified in the occupational evidence of exposure by EHC 130 (1992), since there was no data to deny its toxicity clearly, it was decided that it could not be classified without having sufficient data to put it ouside of the Category.
5 Germ cell mutagenicity Not classified - - - - There was a negative result (EHC 130, 1992) in the dominant lethality test using the mouse which was an in vivo over generation mutagenicity test using the germ cells, and there was no data of the in vivo mutagenicity test using the germ cells and the somatic cells. So we classified it as Out Of Category.
6 Carcinogenicity Not classified - - - - It is classified into A4 (ACGIH 7th, 2001) according to a group 3 (IARC Suppl.7, 1987) and ACGIH and was classified into D (IRIS, 2006) according to IARC by EPA. So it carried out the outside of Category.
7 Reproductive toxicity Not classified - - - - Since there is the description that there is no obvious reproductive toxicity at the dose causing general toxicity to parent animals in the oral administration during pregnancy using rat, mouse, or hamster, and in the rat three generation reproduction study (MOE Risk Assessment The 1st volume (2002), EHC 130 (1992), The rat of DFGOT (vol.18, 2002) and ATSDR (1996)), it is considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, liver, kidney) Danger H370: Causes damage to organs (nervous system, liver, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
According to the descriptions that intense spasm was identifiied in the human evidence of exposure (MOE Risk Assessment (Vol 1,2002), ATSDR (1996), ACGIH (7th, 2001), DFGOT (18 vol. 2002) and EHC 130 (1992)), and that in the animal test by oral administration, neurological symptoms such as spasm and paralysis, and cell necrosis of kidney, infiltration of inflammatory cell, etc such as localized necrosis of liver, inflammatory response, Kupffer cell hyperplasia were identified within the guidance value range of Category 1 (ACGIH (7th, 2001), DFGOT (18 vol. 2002) or ATSDR (1996)). So it was set as Category 1(nerve systems, liver, kidney)
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It was classified to as Category 1 (nervous systems, liver) according to the description that convulsions and hyperexcitability were shown in the oral study using rats, mise, or dogs of DFGOT (vol.18, 2002), ATSDR (1996), EHC 130 (1992), and the description that vacuolation of hepatocyte in the oral study using dogs of the 1st volume (2002) of the MOE Risk Assessment and the description of the liver damage in the oral study using mise of DFGOT (vol.18, 2002) were both acknowledged in guidance value range of Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=0.000037mg/L of Crustacea (Pink shrimp) (EHC130, 1992).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=12600 (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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