GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Nicotine
CAS：54-11-5
Result：
| ID: | 608 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified | - | - | - | - | Flash point: >93degC |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Flash point: 240degC (ICSC (J), 1997) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine and chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Not classified | - | - | - | - | UNRTDG Class: 6.1 |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 1 |
|
Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
There was description that lethal dose by intakes in humans is estimated as 50 to 60 mg (ACGIH (7th, 2001)) or 40 to 60 mg (HSDB (2005), DHP (13th, 2002), and SITTIG (4th, 2002)). The human oral fatal dose was judged to be less than 1mg/kg, it was set as Category 1. |
| 1 | Acute toxicity （Dermal） | Category 1 |
|
Danger | H310: Fatal in contact with skin |
P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Rabbit LD50 value: 50mg/kg and rat LD50 value:140mg/kg (all are PATTY, 4th, 1994). Based on the lower rabbit LD50 value, it was set as Category 1. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | Insufficient data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | The substance was regarded as outside the categories. Because there are no in vivo mutagenicity test data other than a negative report from a dominant lethal test in mice in PATTY (4th, 1994). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the description of eratogenicity was not observed but delay of growth and cerebral rudimentary were observed in the embryo with the dose of decreasing weight gains of mother in the subcutaneous administration study or oral administration study during gestational period in the rats, mice, and rabbits (ACGIH (7th, 2001), PATTY (4th, 1994)) and that most newborns died because secretion of breast milk decreased remarkably in the rat administration study during pregnancy and lactation period (PATTY (4th, 1994)), it was classified into Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, respiratory system, cardiovascular system, gastrointestinal tract), Category 3 (respiratory tract irritation) |
|
Danger Warning |
H370: Causes damage to organs (nervous system, respiratory system, cardiovascular system, gastrointestinal tract) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
According to the description that in an acute intoxication of humans nausea, vomiting, stomachache, diarrhea, the first stage tachypnea, vasoconstriction, elevated BP and nervous agitations appear, and later hypotension, bradycardia, respiratory depression, headach, drowsiness, dizziness, exhaustion of muscles, the action of central nerve systems, irregular rhythms of heart, confusion, etc. are observed (ACGIH (7th, 2001), PATTY (4th, 1994), and HSDB (2005)). So it was set as Category 1 (nervous systems, respiratory systems, cardiovascular systems, elimentary canal). Moreover, since there is a statement of respiratory irritation (HSDB (2005)), it was set as Category 3 (respiratory irritant). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | Insufficient data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |