GHS Classification Result

Chemical Name:Sodium hydroxide
CAS:1310-73-2

Result:
ID: 599
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC, 2000;Hommel, 1991; Weiss, 2nd, 1985)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC, 2000; Hommel, 1991; Weiss, 2nd, 1985)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC (2000))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Water solubility, underwater pH measured value, etc. are performed, and it is stable to water (ICSC (2000), Merck (13th, 2001), etc.).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - Not classified because of UNRTDG Class: 8 though inorganic compounds containing oxygen.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. UNRTDGClass: 8. Corrosive to Aluminum.(ICSC, 2000)

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - It cannot classify according to the guideline, since there is only data of rabbit LD50 value of 325mg/kg but no data of rodent(SIDS, 2002).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the descriptions that at 0.5% or more of concentration, it is irritating to human skin (SIDS, 2002), and causes severe corrosion (DFGOT vol.12, 1999) and that at 8% or more of concentration, it caused corrosion on pig skin (SIDS, 2002) and severe necrosis on rabbit skin with 5% and 4 hour application (ACGIH, 7th, 2001-ATTY, 5th, 2001), it was classified as Category 1A-1C. In addition, sub-categorizing is difficult.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
It was set as Category 1 from description (ACGIH, 7th, 2001;DFGOT vol.12, 1999-ATTY, 5th, 2001) that severe and serious hazard were caused to human's eye, and from description (SIDS, 2002) that corrosive was caused at 1.2% or more to a rabbit eye.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Not classified - - - - It was put outside of the Category based on the description (SIDS, 2002;IUCLID) of no skin sensitisation by the sensitivity test on the human skin.
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories. Based on the negative results from the in vivo micronucleus test in mouse bone-marrow (SIDS, 2002) and the Ames tests, which are in vitro mutagenicity tests) (SIDS, 2002; DFGOT vol.12, 1999).
6 Carcinogenicity Classification not possible - - - - There was a report that carcinogenic is not acknowledged in the administration in drinking drink in water for 12 weeks once per week (DFGOT vol.12, 1999). But it presupposed that data is insufficient and it cannot taxonomic.
7 Reproductive toxicity Classification not possible - - - - Since there is the description that there is no useful data in Reproductive and developmental toxicity (SIDS, 2002;DFGOT vol.12, 1999), it is considered as not to be classified because of insufficient data.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 1(respiratory systems) based on the descriptions that the human respirator and airway are stimulated and lung edemas is caused (SIDS, 2002; ACGIH, 7th, 2001; DFGOT vol.12, 1999; ATTY, 5th, 2001).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although there was description (ACGIH, 7th, 2001;DFGOT vol.12, 1999-ATTY, 5th, 2001) that it injures lungs in the repeated inhalation exposure of rats, it was presupposed not to be classified because of data deficiency.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 48-hour LC50=40.4mg/L of Crustacea (Ceriodaphnia) (SIDS, 2004).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Toxicity factor is considered to be strong base as aqueous solution, but toxic effect is eased by the buffer action in the environmental water.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information