GHS Classification Result

Chemical Name:Bromine
CAS:7726-95-6

Result:
ID: 596
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Not combustible.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Not combustible
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not combustible.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible - - - - Although oxygen, fluoride, and chlorine are not included, they are indicated to Enhances combustion of other substances on the ICSC cards. It is an oxidizing liquid. However, in UNRTDG, subsidiary risks nature 5.1 is not attached to the UN number 1744. Although it was thought that oxidizing powers did not exceed 65% nitrate which is a minimum standard substance of PG III, there was no released data. So it presupposed "It cannot classify." Although a possibility of be in outer category is large, references to risk of combustion aids should be attached to MSDS.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Category 1 Warning H290: May be corrosive to metals P234: Keep only in original container.
P390: Absorb spillage to prevent material-damage.
P406: Store in corrosive resistant/... container with a resistant inner liner.
It is not necessary to do the examination defined in the United Nations, and is judged as "Category 1". Because reacting violently with aluminum is known (Bretherick (J) (1998)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
There are the value of 1700 mg/kg (RTECS (2004)) and 2600 mg/kg (IUCLID (2000)) in oral LD50 of rats. The lower one was adopted and it was set as Category 3.
1 Acute toxicity (Dermal) Classification not possible - - - - There is no transdermal absorptions lethal toxicity data, and it cannot be classified.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
There was no suitable data for rats. So two mice data (ACGIH (2001)) were converted for 4 hours, and LC50: 120ppm and 61.5ppm were obtained. And it was classified as Category 1 based on he lower one. T+; R26 is used in the EU risk phrase.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
The experimental result on rats is a stimulation (IUCLID (2000)). But there is a statement of skin corrosion on humans (Patty (5th.2001), HSDB (2005), HSFS (1998)), and the risks phrases of R35 was applied in EU. So it was classified as Category 1. There is no test data with sub-category A-C. But it is designated to be class 8 PG Division I by UNRTDG. So it is considered to be Category 1A.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
The animal experiment in ACGIH (2001) is exposure to a vapor, and is not what medicated the eye with the liquid. It is indicated as the eye stimulus in another part. HSFS (1998) also has severe eye description of stimulus. Since Category of a skin stimulus is 1, an eye is also set to "Category 1" by provision of GHS.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - The substance cannot be classified because there are no test reports about the mutagenicity.
6 Carcinogenicity Classification not possible - - - - Since there was no test reports and there was also no evaluation result, and it presupposed "It cannot classify." Mr. Shirasu's experimental result recorded and selected by IUCLID (2000) is an evaluation of a fumatory agent and a methyl bromide, and is not a thing about an elements d bromine.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data on toxic to rproduction and epidemiology.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, central nervous system) Danger H370: Causes damage to organs (respiratory system, central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
By the animal experiments with an exposure amount (300ppm) which is less than the guidance value (2500ppm) of Category 1, dysfunction of the central nerve system, damages to lungs and bronchus, and bleeding in gastrointestinal mucosa are observed (ACGIH (2001)). Symptoms in connection with the respiratory organ-system and central nerve system are also indicated by humans (Patty (5th.2001)). So it was set as "Category 1(a central nervous system, respiratory-organ system)". The respiratory tract irritation was included in the respiratory systems. The effect on the digestive system is not adopted as organ toxicity because it is caused by the corrosiveness of this substance.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, nervous system, endocrine system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, nervous system, endocrine system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since it is reported of the effects on the respiratory, nervous and endcrine systems in the animal experiments of exposures which is below the guidance value (10mg of oral/kg/d, 50 ppm of inhalation (steam) / 6 h/d) of Category 1(ACGIH (2001), Patty (5th.2001)) , it was classified to as Category 1 regarding these as target organs.
10 Aspiration hazard Classification not possible - - - - There is the statements of chemical pneumonia by steam inhalation (IUCLID (2000)), but there was no report of the influence by aspiration and we could not classify it.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour LC50=1000microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, and behavior in water and bioaccumulative potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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