GHS Classification Result

Chemical Name：Ethane, bromo-
CAS：74-96-4

Result：
ID: 593
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 2 because of its flash point: <23degC and initial Boiling point: >35degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - There is data which says the ignition points is 511degC and it is thought that it does not ignite in room temperatures.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - There is no examination data of metal corrosiveness and it cannot be classified. There is information that it reacts as promptly as with aluminum powders (IARC 52 (1991)), and there is fear of metal corrosion.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Category 4 based on SPECIES: Rat; ENDPOINT: LD50;:1350mg/kg; REFERENCE SOURCE: CICADS 42 (2002)
1 Acute toxicity （Dermal） Classification not possible - - - - There is no quantitive experimental data and it cannot be classified. In addition, there is a report that this substance contact to the rabbit skin for 6 hours and toxic effects was not seen (CICADS 42 (2002)). But ACGIH attaches Notation of Skin. so the bad influence by skin exposure in long-term/repetition is considered.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. There is rat inhalation data that is converted to 8273ppm for 4 hours. Other two data are close to 13500ppm, which is a little more than 2.5 times the maximum of Category 4: 5000ppm (CICADS 42 (2002), IARC 52 (1991)), it was classified as Category 5.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. There is a test result of irritant and non-irritant on rabbits (CICADS 42 (2002)). And it was classified as Category 3 based on the statement of "skin irritant" on humans (Patty (5th.2001)).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Although the quantitive experiment report was not obtained, it was set as "Category 2A-2B" by the statement of eye irritant about humans (ICSC (2001), CICADS 42 (2002), ACGIH (2001), Patty (5th.2001)).
4 Respiratory sensitization Classification not possible - - - - It cannot be classified because examination data and epidemiology information cannot be obtained.
4 Skin sensitization Classification not possible - - - - It cannot be classified because examination data and epidemiology information cannot be obtained.
5 Germ cell mutagenicity Classification not possible - - - - The only in vivo test results which have been found were from experiments with drosophila (CICADS 42 (2002)). In in vitro tests, there is one strong positive result from the Ames test (0.185 revertants/nmol (review of original text by Dr. Sofuni)) but the chromosome aberration test is negative (IARC 52 (1991)). So it cannot be considered that there are several positive results. It was decided that the substance could not be classified according to the experts comments.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		A carcinogenic examination using rats and mice was performed by NTP (TR-363 (1989)), ACGIH is estimating it as A3 based on this result. EU has classified into Car.Cat.3. It was set as "2" from these. Since IARC does not have several studies reports, it is concluded that it classified into 3.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since, testicular atrophy in the male rat is reported (NTP-TR-363 (1989)) and this is considered to be the influence on the reproduction potential of male (CICADS 42 (2002)), it was classified into "Category 2". There is an epidemiologic report of adverse effect to the female workers in pregnancy (ACGIH (2001)). However, since it was a mixed exposure with other solvents, it removed from the evidence of evaluation
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, respiratory system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (nervous system, respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		The influence from anesthetic on the peripheral and central nerves is reported in a human case (ACGIH (2001)). Moreover, since the respiratory-organs stimulus and the lung stimulus were also described (Patty (5th.2001)). So it was set as "Category 1 (nerve system, the respiratory system) and Category 3 (anesthetic)". Anesthesia is identified in the animal inhalation experiments, too.
9 Specific target organ toxicity - Repeated exposure Category 2 (central nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since HSDB (2005) has the description which suggests a chronic effects on the central nervous systems in humans, and an ACGIH-TVL advice value has the statement of "CNS impair", it was classified to as Category 2 (central nervous systems). Although "hepatic dysfunction" was mentioned in the TLV advice value, it was withheld to use for classification since the inhalation exposure test for rats, which is used as an evidence, was carried out overdose the guidance value of 2, 583 ppm * 4 hours /a day.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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