GHS Classification Result

Chemical Name:paraquat-dimethylsulfate
CAS:2074-50-2

Result:
ID: 592
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible
11 Self-heating substances and mixtures Not classified - - - - Not combustible.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - It does not contains fluorine and chlorine. Although it contains oxygen as sulfate ester, this nonion is not considered as an oxidizer.
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Statistics calculation of the data (ACGIH (2001), EHC 39 (1984)) of four examinations was done, and 230.3mg/kg was obtained. It is set as Category 3.
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Statistics calculation of three data (ACGIH (2001), EHC 39 (1984)) was done, and 214.5mg/kg was obtained. It is set to Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - There is no acute inhalation test data for steam, and it cannot be classified. Vapor pressure is very low and a fatal dose of steam will not be generated at normal temperature.
1 Acute toxicity (Inhalation: Dusts and mists) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 1 since all three data (ACGIH (2001), EHC 39 (1984)) were 0.05mg/L or less except the time when dust sizes is large.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Since there was information that it stimulated human skin (ACGIH (2001)) and animal skin (EHC 39 (1984)), it was classified as "Category 2." In repeated exposure, skin necrosis is also seen on rats and mice. (EHC 39(1984))
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
The stimulus of the eye was reported with humans (ACGIH (2001)) and rabbits (EHC 39 (1984)). But the rabbit had recovered in 4 days, it was set to "Category 2B."
4 Respiratory sensitization Classification not possible - - - - There is no information and it cannot be classified.
4 Skin sensitization Not classified - - - - It was put "outside of the Category" because there is a report that sensitization was not observed with guinea pigs (EHC 39 (1984)).
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as "outside the categories". Because there are negative results from dominant lethal tests in mice and in vivo bone-marrow tests (EHC 39 (1984)). No positive results have been found in in vitro tests either.
6 Carcinogenicity Classification not possible - - - - Since paraquat has been classified into C by EPA, it becomes the outside of Category. However, about methyl sulfates of counterion, each evaluation agencies has categorized dimethyl sulfates analogue into carcinogenic. The evaluation about Paraquat = 2 methyl hydrogen sulfate has not been performed.
7 Reproductive toxicity Not classified - - - - Since there is no bad effect in oral administration experiment in three generation of rat (EHC 39 (1984)), it is considered as "out of the Category."
8 Specific target organ toxicity - Single exposure Category 1 (kidney, liver, respiratory system) Danger H370: Causes damage to organs (kidney, liver, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Kidney, liver, and lungs were common with each recovery case of the human accident exposure (EHC 39 (1984)). Since the respiratory disorders are mentioned in examples of accidents (ACGIH (2001)), lungs were unified with this and put to "Category 1 (kidney, liver, respiratory system)."
9 Specific target organ toxicity - Repeated exposure Category 1 (lung, kidney, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (lung, kidney, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
It was classified to as Category 1 (lungs, kidney, liver), because of the harmful effects in lungs, kidney, and liver by serum chemistry (ChE, GPT) and by pathological examination (EHC 39 (1984)) in the repeated oral administration experiment for rats within the guidance value of Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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