GHS Classification Result

Chemical Name:Parathion, methyl-
CAS:298-00-0

Result:
ID: 591
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - No data available
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Not classified because of "Non-combustible" (ICSC (1997)
8 Self-reactive substances and mixtures Classification not possible - - - - No data available
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - There are statements like "it burns but ignites easily." (NAEGR (J) (2001)) or like "Not flammable at normal temperature" (HSDB (2005)), and even if it contacts air at room temperature, it does not ignite spontaneously.
11 Self-heating substances and mixtures Classification not possible - - - - Since the melting points are 37 - 38 degC (Merck (13th, 2001)), and 140 degC or less, the test for which it was suitable has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since the sexual differences which exceed the differences between examinations in rat LD50 value (EHC 145 (1993), ATSDR (2001), JMPR 902 (1995)) of 15 examples which were made to classification target is not observed, It was set as Category 2 based on 11.2 mg/kg obtained by statistical calculation to male and female.
1 Acute toxicity (Dermal) Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
The statistical work including male and female was done and 66.4mg/kg was obtained. (In the LD50 value using eight rats (EHC 145 (1993), ATSDR (2001), JMPR 902 (1995)), the sexual differences which exceed the examinations difference was not observed.) On the other hand, there was rabbit LD50 = 300mg/kg. It was set as Category 2 since lower calculated rat value 66.4mg/kg was adopted.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
The sexual differences which exceeds the difference during an examination on 11 rat LC50 value (EHC 145 (1993), ATSDR (2001), JMPR 902 (1995)) is not acknowledged. It was set as Category 2 based on 0.0611mg/L calculated by statistical work including males and females.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. In rabbit skin application test, descriptions "although very slight to moderate erythema was observed, all recovered within 48 hours" and "mild irritation" are found. Therefore it was classified as Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description (JMPR 902 (1995)) of "mild redness was acknowledged, but it recovered in 48 hours"for rabbit eye drop, it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - It cannot be classified.
4 Skin sensitization Not classified - - - - Based on the fact that sensitizing was not observed in the guinea pig skin sensitization test of Magnusson-Kligman(JMPR 902 (1995)) , and that sensitizing was not also found from the result of having examined the possibility of allergy in 200 humans (EHC 145 (1993)), it was put outside of the Category.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
The substance was classified as Category 2. Based on the positive results from the in vivo micronucleus test in rats and mice and the in vivo chromosome aberration test in rats (both are in vivo mutagenicity tests in somatic cells) (ATSDR (2001), EHC 145(1993)). The results of the epidemiological studies indicating the abnormal increases of chromosome aberrations in exposed human peripheral blood lymphocytes (ATSDR (2001, EHC 145(1993)) also support this classification.
6 Carcinogenicity Not classified - - - - Since it is classified into 3 according to IARC (1987) and was classified into A4 according to ACGIH (1996), respectively, it carried out the outside of Category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the three-generation reproduction study of rats, decreased number of litter size and reduction of litters viability were observed (EHC 145 (1993)) and with exposures in pregnancy, lincreased embryo absorption and embryo loss in post-implantation are also observed (JMPR 902 (1995), JMPR 902 (1995), ATSDR (2001)). Although there is also a report which is not mentioned about the general toxicity in the parental animals at such effective dosage, there are reports about the facts of inhibition of weight gain in mother animal, and development of cholinergic symptom(JMPR 902 (1995), ATSDR (2001)). Therefore, it was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Both humans and animals caused a significant reduction in cholinesterase activity by exposure to methyl parathion (EHC 145 (1993), PATTY (5th, 2001), ATSDR (2001)), and showed the neural symptoms of cholinergic property as a result (PATTY (5th, 2001), ATSDR (2001)), and have resulted in death (ATSDR (2001)). With reference to the guidance value from the dose which marked a significant reduction in cholinesterase activities in the single exposure test to the rat, it was set as Category 1 (nervous systems).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Inhibition of the cholinesterase activities is looked by exposure regardless of an animal species or an administration route (EHC 145 (1993), JMPR 902 (1995), ATSDR (2001)). When the influence is strong, within the dose which is equivalent to the guidance value Category 1, it has affected neurologic symptoms such as a tremor and hyperactivity (JMPR 902 (1995), ATSDR (2001), EHC 145 (1993)), or peripheral neuropathy (sciatic nerve) is observed histopathologically (EHC 145 (1993), JMPR 902 (1995)). Moreover, inhibition of the cholinesterase activities is mainly reported not a little in humans by occupational exposure (EHC 145 (1993), ACGIH (2001)). It was classified to as Category 1 (nerve systems) based on the above facts.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour LC50=0.14microg/Lof Crustacea (Daphnia magna) (EHC 145 and 1993) .
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=2.86(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

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