NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Dibromochloropropane
CAS：96-12-8

Result：


ID:	587
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 4	-	Warning	H227: Combustible liquid	P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ...	Category 4 because of its flash point: >60degC and <90degC
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not classified	-	-	-	-	UNRTDG : it is classified into a class 6.1 (Toxic substances) and PG 2 or 3.
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon (but not to other elements).
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Containing no -0-0- structure
16	Corrosive to metals	Not classified	-	-	-	-	UNRTDG Class: 6.1 (Toxic substances), PG II or III

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 185 mg/kg; REFERENCE SOURCE: ATSDR (1992)
1	Acute toxicity （Dermal）	Category 4		Warning	H312: Harmful in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	It was set as Category 4 based on rabbits dermal LD50 = 1400mg/kg (ATSDR (1992)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was classified as Category 2 based on rat inhalation LC50 = 154ppm (ATSDR (1992)).
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Not classified	-	-	-	-	When it was applied to the normal skin in rabbit test, there was no irritation, and since even when it was applied to the brushing skin, only very slight erythema was observed. Therefore, it was classified as out of Category.
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Mild irritation was acknowledged in the conjunctiva and the iris of the rabbit. But it recovered completely in one to two days (ATSDR (1992)). So it was set as Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Category 1B		Danger	H340: May cause genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	The substance was classified as Category 1B. Based on the positive results from the in vivo multi-generation mutagenicity test using germ cells (the rat dominant lethal test (IARC 71(1999)), the in vivo mutagenicity test using germ cells (the chromosome aberration test using rat spermatogenic cells (IARC 71(1999)), and the in vivo mutagenicity tests in somatic cells (the mouse spot test, micronucleus test using mouse or rat bone-marrow cells (IARC 71(1999)).
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since the IARC classification is 2B, the Japanese industrial hygene academic Society classification is 2B, and the NTP classification is R, it was to category 2.
7	Reproductive toxicity	Category 1A		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In humans, azoospermia and oligospermia are observed and the possibility of infertility is suggested (IARC 71 (1999), IRIS (2003)). Moreover, it is reported in a reference that although this is reproductive toxicity product to male and also it effects to infertility, it does not have an adverse effects on reproduction of male offspring (Chemically Induced Birth Defects-3rd edition), indirect correlation is observed between exposure and a sperm count (Catalog of Teratogenic Agents, 11th edition). Furthermore, it clearly describes "The spermatogenesis is inhibited in humans, and infertility is occured" (IARC 71 (1999)). Therefore, it was classified into Category 1A.
8	Specific target organ toxicity - Single exposure	Category 3 （Respiratory tract irritation）		Warning	H335: May cause respiratory irritation (respiratory tract irritation)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	In the rat inhalation study, since the respiratory irritation was reported (ATSDR (1992)), it was classified into Category 3 (respiratory irritant).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system, kidney, liver, central nervous system, blood system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, liver, central nervous system, blood system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In the test of repetitive inhalation exposure to rats or mise, the influence on the respiratory systemssuch as a necrosis of a nasal cavity and a trachea, pulmonary emphysema, and pneumonia (IARC 71 (1999), ATSDR (1992)), the nephrosis in kidney and nephropathia (ATSDR (1992)), the necrosis in liver (ATSDR (1992)) , meningoencephalitis and brain necrosis (ATSDR (1992)), anemia, and atrophy of the spleen (ATSDR (1992)) are accepted in the equivalent concentration for the guidance value range of Category 1. It was referred to as Category 1 (respiratory system, kidney, liver, central nervous systems, and blood systems) based on these results.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 3 from 48-hour EC50=19mg/L of Crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 1999).
11	Hazardous to the aquatic environment （Long-term）	Category 3	-	-	H412: Harmful to aquatic life with long lasting effects	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Classified into Category 3, since acute toxicity was Category 3 and supposed not rapidly degrading (BIOWIN), though less bio-accumulative (BCF=19 (existing chemical safety inspections data)).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）