GHS Classification Result

Chemical Name：Ethane, 1,2-dibromo-
CAS：106-93-4

Result：
ID: 586
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Non-combustible (Hommel, 1991).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Non-combustible (Hommel, 1991)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (Hommel, 1991)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Not classified - - - - UNRTDG Class: 6.1, PGI

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rat LD50 values of 146 mg/kg (male), 117 mg/kg (female), and 140 mg/kg (male and female) (EHC 177 (1996)) corresponded to classification target, and it was set as Category 3 based on the lowest value of 117 mg/kg.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 based on rabbit LD50= 450mg/kg (EHC 177 (1996)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Rat LC50 value 2.304mg/L and 4.620mg/L (4-hour equivalent of 2.31mg/L) (EHC 177 (1996)) corresponded as subjects of classification. Both were equivalent to about 300ppm, and it was classified as Category 2 with the application of the gaseous classification Category. [saturated vapor pressure concentration: 10^(6) *1.5 / 101(kPa) = 14851ppm]
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Although significant irritation accompanied by erythema and edema which progress to necrosis and eschar was observed with repetitive application on shaved rabbit abdominal, it is described that it recovered completely within seven days after the end of exposure (EHC 177 (1996)). On humans, from the results of single exposure test on skin, it is judged to have serious stimulativeness (IUCLID (2000)), and other reports indicate severe irritation (EHC 177 (1996), PATTY (5th, 2001), ATSDR (1992)). From these information, this product may result in corrosion. So it was judged to have severe irritation, it was classified as Category 2.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is irritation on the conjunctiva and necrotic slight for corneal surfaces by rabbits eye drops, it did not bequeath injury 12 days afterward, and had recovered completely (EHC 177 (1996)). Moreover, it is indicated that there is ocular severe irritation in humans (EHC 177 (1996)). Since it was judged that it had the moderates irritation from these information to an eye, it was set as Category 2.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although there is a report (BUA 66 (1991)) which suggests sensitizing by humans, it cannot be said that the accuracy as a proof is sufficient, and since data is insufficient, it cannot be classified..
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There are positive results from the DNA damage test using rat testicular cells (in vivo genotoxicity test in germ cells) and from several DNA damage tests and DNA binding tests using somatic cells such as hepatocytes from rats or mice (in vivo genotoxicity test in somatic cells) (IARC 71(1999), EHC 177(1996)). Furthermore, there are positive results in several parameters for the in vitro mutagenicity tests (IARC 71(1999), EHC 177(1996)). The substance was classified as Category 2 based on the above results.
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 1B based on being classified into 2A (2002) according to industrial hygene society, and being classified into 2A (1999) according to IARC, respectively.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is the report about the failure of pregnancy in the mating between the male rat exposed with ten-week inhalation and the female rat no processing, and the decrease of mating formation in the mating between the female rat exposed with three-week inhalation and the male rat no processing (EHC 177(1996)). Since general toxicity (reduced weight gain, dead) occurs spontaneously in the dose causing these effects, it is classified into the Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (liver, kidney, central nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (liver, kidney, central nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Due to the descriptions that the liver fatty metamorphosis, centrilobular necrosis, and proximal convoluted tubules of kidneys were observed by suicide attempt or mistaking (EHC 177(1996), PATTY (5th, 2001), IARC 71(1999), ACGIH (2001), BUA 66 (1991)), and that centrilobular fatty change degenerations and necrosis in hepatic and renal tubule edema in liver were observed also in rat (EHC 177 (1996)). So it was classified into Category 1 (liver, kidney). Moreover, due to the descriptons that there are some reports which mistaking for the anesthetic in humans caused poisoning (ACGIH (2001), BUA 66 (1991)), furthermore, that it affects to central nervous systems and causes an awareness decreases is caused (ICSC (1993)), it was classified into Category 1 (central nervous system). In addition, it also classified into Category 3 (respiratory irritant) according to the description which also has irritaiton in airways (EHC 177 (1996), ICSC (1993)).
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory system, liver, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (respiratory system, liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified in Category 2 (respiratory tracts) based on statements that not only stimulative to the pharynx and a bronchus (PATTY (5th, 2001)), but also lungs damage and bronchitis were affected in humans by occupational exposure (ICSC (1993)), and statements that a necrosis and atrophy of olfactory epithelium in nasal cavity, dysplasia, hyperplasia, and gigantocellularis of a squamous epithelium cell in a respiratory tract were seen in inhalation exposure of rats or mouse with the concentration (0.577 mg/L) equivalent to the guidance value Category 2 (EHC 177 (1996)) . Moreover, a potential that humans will also affect liver and the kidney as effect of long-term or repeated exposure is suggested (ICSC (1993)), and inhalation exposure of a guinea pigs with the concentration (0.385 mg/L (50 ppm) (80 days) (the equivalent on the 90 days: 0.342 mg/L)) as equivalent to the guidance value Category 2, mild centrilobular fatty degeneration in liver, interstitial congestion and edema in the kidney were observed (EHC 177 (1996)). On this bases, it was classified in Category 2 (liver, kidney).
10 Aspiration hazard Classification not possible - - - - Insufficient data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96-hour LC50=32.1mg/L of fishes (Oryzias latipes) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Based on NOEC=5.81 mg/L during 28 days for the fish (Oryzias latipes) (ECETOC TR91, 2003), though acute toxicity was Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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