GHS Classification Result

Chemical Name：Chloroprene
CAS：126-99-8

Result：
ID: 576
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - UNRTDG Class: 3, Subsidiary risks Class: 6.1
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Category 2 because of its flash point: -20degC and initial boiling point: 59 to 59.4degC. Category 1 based on UNRTDG Class: 3, PG I.
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Not classified based on UNRTDG Class: 3, Subsidiary risks Class: 6.1, though containing unsaturated C=C bonds as chemical groups associated with self-reactive properties present
9 Pyrophoric liquids Not classified - - - - Flash point: 440degC (Hommel, 1991)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Not classified because of UNRTDG Class: 3, Subsidiary risks Class: 6.1
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 based on LD50= 251mg/kg obtained from the calculation using LD50 value of 2 examinations with rats (SIDS (2003)).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 2 based on rat LD50= 200mg/kg (SIDS (2003)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The saturated vapor pressure concentration of this product is 264356ppm, and it is thought that all inhalation tests were done with vapor. It was classified as Category 3 based on LC50 = 8.2mg/L (2280ppm) calculated from rat LC50 values of 2 examinations which performed 4 hour exposure (SIDS (2003), IARC 19 (1979)).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Mild to moderate erythema and edemas for rabbits and the thickening of the skin with repeated administration to the mouse are reported (SIDS (2003)). And dermatitis and alopecia were seen on humans (IARC 19 (1979)). It was classified as Category 2 because there is no finding of corrosivity.
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Although conjunctivitis was produced with the rabbit, a duration of the problem has a statement that it was for ten days (SIDS (2003)). Moreover, irritation and pains were produced in the eye by vapor exposure in the rat (PATTY (5th, 2001)) But .the stimulative grade is unknown. So it was set as Category 2A-2B based on these data.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1B. Because there are no multi-generation epidemiological data for humans and there are positive results from the in vivo dominant lethal tests in rodents (SIDS (2003), ACGIH (2001)).
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into 2B according to IARC (IARC 71 (1999)), and into 2B according to an industrial hygene academic society (JETOC specially data No.190 (2004)), and was classified into 2 according to EU (EU-Annex I (2006)). Newest EU was employed and it was set as Category 1B.
7 Reproductive toxicity Category 1A Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is the report that there is no disorder of reproductive potential of parent, embryotoxicity, and teratogenicity (ACGIH (2001), PATTY (5th, 2001), IARC 19 (1999)). But in many other reports, there is the description of inhibition of spermatogenesis of male rat (ACGIH (2001)), of the examples of mating impossibility and sterility of male rat and male mouse (ACGIH (2001)), and embryotoxicity as embryonic lethallity etc. and malformation as hydrocephalus and meningoencephalocele etc. (ACGIH (2001), SIDS (2003), IARC 19 (1999)). There is the description that it occure dysorders of spermatogenesis and it is observed sperm morphological defect on humans, and there is a lot of natural abortion among the wives of chloroprene laborers (IARC 19 (1979)). It is classified into the Category 1A from these information.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, respiratory system, liver, kidney) Danger H370: Causes damage to organs (central nervous system, respiratory system, liver, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the descriptions that it shows the central nervous systems depressions in dosage range of guidance value in Category 1 in rat, mouse, and rabbit (IARC 19 (1979)), and that it shows central nervous system depressant action also in human (IARC 19 (1979)), it was classified into Category 1 (central nervous systems). Due to the descriptions that it causes liver damage in dosage range of the guidance value of Category 1 in rat (ACGIH (2001)), and that it cases damage to liver, lungs, and the kidney in human (IARC 19 (1979)), it was classified into Category 1(liver, lungs, kidney). Due to the descriptions that it affects the airway in dosage range of the guidance value of Cagegory 1 in rat (PATTY (5th, 2001)), and that it develops dyspnea by stimulates mucosa (IARC 19 (1979)), it was classified into Category 3 (airway stimulativeness). In addition, since there is no description of specific conditions about central nervous systems or the degree of inhibition and no description of related-anesthetic actions, it was classified into Category 1 (central nervous system). Category 1 (lung) and Category 3 (respiratory irritant) were classified into Category 1 (respiratory systems).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, cardiovascular system, tooth, nerve of tooth, immune system, lung, liver, stomach), Category 2 (blood, olfactory organ, respiratory system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system, cardiovascular system, tooth, nerve of tooth, immune system, lung, liver, stomach)
H373: May cause damage to organs through prolonged or repeated exposure (blood, olfactory organ, respiratory system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classfied in Category 1(nervous systems,cardiovascular systems) based on the statement that pathological changes was seen in the cardiovascular system and the nervous system in humans (IARC 19 (1979)) and the statementthat there were complaints of neurological symptoms such as headache, giddiness, and insomnia, and a rapid pulse, and chest pain (IARC 19 (1979)) . Since there was the statement of a dental corrosion, gingivitis, a periodontal membrane flame, and a decreased immunoreaction in humans (IARC 19 (1979)) , it was classified in Category 1 (a tooth, periodontal tissue, immunity system). Since there are the statement that plasma cholinesterase reduction in activity was seen in humans (IARC 19 (1979)) , and the statement that the necrobiosis in liver was seen in the amount of exposure of the guidance value range of Category 1in the rat and a hamster and the organization obstacle of lungs in the rat (PATTY (5th, 2001)), it was classified in Category 1 (lungs,liver). It was classified in Category 1 (stomach) and Category 2 (blood, olfactus organ) based on the statement that the abnormalities in blood coagulation, the denaturation and fault formation of a sense-of-smell epithelium, and fault formation of the front gastric epithelium were seen in a rat in the amount of exposure of the guidance value range of Category 2(PATTY (5th, 2001)) , and the statement that gastrointestinal disorders was seen in humans (IARC 19 (1979)). Based on the statement of the inflammation of a nasal cavity in the amount of exposure of the guidance value range of Category 2 in a rat (PATTY (5th, 2001)), it was classified in Category 2 (respiratory tracts).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It carried out the outside of Category from 96-hour LC50=245mg/L of fishes (Bluegill) (SIDS, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since not water-insoluble (aqueous solubility = 874.9 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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