GHS Classification Result

Chemical Name：Hydrogen peroxide
CAS：7722-84-1

Result：
ID: 573
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Not classified based on UNRTDG Class: 5.1, Subsidiary risks Class: 8. However, the substance could be classified as explosives since it contains -O-O- bonds as chemical groups associated with explosive properties present.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Non-combustible (ICSC(J), 2000; Hommel, 1991).
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - Not classified based on UNRTDG Class: 5.1, Subsidiary risks Class: 8, though containing -O-O- bonds as chemical groups associated with explosive properties present
9 Pyrophoric liquids Not classified - - - - Non-combustible (ICSC (J), 2000; Hommel, 1991)
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC(J), 2000; Hommel, 1991)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metal or half-metal (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) is not included. The physical-properties value (boiling point, melting point, viscosity, others) of the solution of the various concentration of this substance is judged to be a stable in the water based on being adopted as much of the literature as universal values.
13 Oxidizing liquids Category 1 Danger H271: May cause fire or explosion; strong oxidizer P371+P380+P375: In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
P306+P360: IF ON CLOTHING: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P283: Wear fire/flame resistant/retardant clothing.
P501: Dispose of contents/container to ... 		Category 1 based on GHS Classification manual. UNRTDG No. 2015, Class: 5.1, Subsidiary risks Class: 8, PG I(HYDROGEN PEROXIDE,STABILIZED or HYDROGEN PEROXIDE,AQUEOUS SOLUTION,STABILIZED with more than 60% hydrogen peroxide)
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Inorganic substance
16 Corrosive to metals Classification not possible - - - - Although it is considered as UNRTDG class 5.1 (subsidiary risks 8), this subfollowing classification is considered based on skin corrosivenesses. Since there is no data about corrosion behavior, it cannot be classified.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was set as Category 4 based on LD50 = 311mg/kg obtained from the calculation using four rat data (EU-RAR (2003)).
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was set as Category 5 based on rat LD50= 4060mg/kg (EU-RAR (2003)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The saturated vapor pressure concentration of this product is 1980ppm. And it was classified as Category 3 based on rat LC50 = 1438ppm of obtained by the test considered to have been performed with steam (EU-RAR (2003)).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The conclusion with necrosis which penetrates to all layers of the skin or corrosivity is indicated in 3 minute, 1 hour, or 4 hour application on rabbits (EU-RAR (2003), ECETOC Special Report 10 (1996)), and in EU, it is classified as C; R35, therefore, this product is thought to have corrosivity on skin. However, since information is insufficient to subcategorize, it was classified as Category 1A-1C.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		This product is a skin corrosive substance. There is a publication that severe irritation for an animal and it is corrosive (ECETOC JACC (1993), EU-RAR (2003)). It was set as Category 1 based on the above information.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - With the guinea pigs, there are negative results (EU-RAR (2003), ECETOC JACC (1993)) by two examinations, and it is indicated in humans that a large group of persons was negative in the patch test (EU-RAR (2003)). However, there is also a statement (EU-RAR (2003)) that two examples were positive among 158 examples in the human patch test, and since data is insufficient, it cannot be classified.
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories. Because there are no results from multi-generation epidemiological and mutagenicity tests in humans and in vivo mutagenicity tests in germ cells, and there is a report of a negative result from a micronucleus test in mice (EU-RAR (2003), ECETOC Special Report 10 (1996)), and there are no positive results from in vivo genotoxicity tests in germ cells.
6 Carcinogenicity Not classified - - - - It was classified into 3 according to IARC, and classified into A3 according to ACGIH. IARC which has newer classification year was adopted and it was set as the outside of Category by the technical guideline.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is the description that the effect to human sperm is observed in the in vitro experiment (ECETOC JACC (1993)), and there is no description about the general toxicity to parent animals in the animal test, but based on the description that there is the effect to sperm motility, the effedct to estrousl cycle of female, the effect to the decrease of the number of delivery maternal animal, and the weight decrease of offspring, (ECETOC JACC (1993)), it is classified into the Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, central nervous system) Danger H370: Causes damage to organs (respiratory system, central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The irritations to the nose, the throat, and the tracheal are reported in human (ACGIH (2001)) and animal (EU-RAR (2003)). In animals, there are the descriptions that it causes the congestion, pneumonedema, emphysema of lung and tracheal and necrosis of tract epithelium within the guidance level of Category 1 (EU-RAR (2003), ECETOC Special Report 10 (1996)). It was classified into Category 1 (respiratory tracts) based on these results. Based on the descriptions of headache, giddiness, tremor, spasm, coma, and cerebral infarction in humans (ACGIH (2001), EU-RAR (2003)), it was classified into Category 1(central nervous systems).
9 Specific target organ toxicity - Repeated exposure Category 1 (lung), Category 2 (blood) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (lung)
H373: May cause damage to organs through prolonged or repeated exposure (blood) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since a fibrous tissues appears here and there in pneumoconiosiss with the dosage of guidance value range of Category 1 in the inhalation testof steam in a dog (EU-RAR (2003)) , and there was the statement that mixture of atelectatic lung area and emphysema area is seen and it has irritation in lung also in humans (ECETOC JACC (1993)) , it was classified in Category 1 (lung). It was classified in Category 2 (blood) on the basis that effect was seen on the white blood cell counts and the hematocrit values by oral administration in rats with the dosage of the guidance value range of Category 2 and hemolytic was seen (EU-RAR (2003)).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48-hour EC50=2.4mg/L of Crustacea (Water flea) (EU-RAR, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Rapidly degrading in water.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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