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GHS Classification Result

Chemical Name：Phosphoryl trichloride
CAS：10025-87-3

Result：


ID:	569
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	-	-	-	-	Non-combustible (Weiss, 2nd, 1985).
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not classified	-	-	-	-	Non-combustible (Weiss (2nd, 1985)
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Non-combustible (Weiss, 2nd, 1985)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Metal or half-metal (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) is not included. Although it reacts intensely to the water (dangerous DB (the 2nd edition, 1993)), the occurring gas is hydrogen chlorides (inert gas).
13	Oxidizing liquids	Not classified	-	-	-	-	Not classified because of UNRTDG Class: 8 though inorganic compounds containing oxygen and chlorine.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic substance
16	Corrosive to metals	Classification not possible	-	-	-	-	Classification not possible due to lack of data metal corrosion. UNRTDG Class: 8.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	SPECIES: Rat ENDPOINT: LD50 VALUE: 380 mg/kg REFERENCE SOURCE: RTECS (2005), IUCLID (2000)
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Category 1		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Since the saturated vapor pressure concentration of this product is 5248ppm, it is thought that the inhalation test was by with vapor. It was classified as Category 1 based on rat LC50 = 48ppm (ACGIH (7th, 2001)).
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 1A-1C		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the descriptions that it indicates corrosivity and severe irritation on animals (IUCLID (2000)) and also on humans (ACGIH (7th, 2001) and HSDB (2000), Institut national de recherche, and CDROMCD 613 (May 2000.3p.)), it was classified as Category 1A-1C.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	This product is a skin corrosive substance. With a rabbit, there is a statement of strong eye stimulativeness and a strong necrosis, and loss of eyesight (IUCLID (2000), GESTIS (2005)), and with humans, there is a statement of strong eye stimulativeness, corrosiveness, and loss of eyesight is (ACGIH (7th, 2001), ICSC (J), (2002), HSDB (2005)). So it was set as Category 1.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data available
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory system)		Danger	H370: Causes damage to organs (central nervous system, respiratory system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	The effects to the central nervous systems on dizziness, headaches, loss of appetite, weakness, nausea, vomiting, etc. are described in humans (ICSC (J) (2002), HSDB (2005)), and since the denaturation of the nerve cell was observed in the repeat-dose studies in the rat, it was classified into Category 1 (central nervous system). Due to the descriptions that chest pain, cough, breathing difficulties, bronchitis, bronchopneumonia and pulmonary edema are observed in humans (ACGIH (2001)), and that breathing difficulties is described in guinea pigs (RTECS (2005)). So it was classified into Category 1 (respiratory systems).
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, respiratory system, kidney)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, respiratory system, kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Since symptoms, such as giddiness, headache, loss of appetite, sluggishness, nausea, and vomiting, etc., in humans was indicated (ACGIH and (7th 2001), (HSDV(2005)), and there was the statement (IUCLID (2000)) that the degeneration of the brain-cell was seen in the rat with the dose of guidance value range of category 1, it was classified in Category 1 (central nervous systems). It was classified into Category 1 (respiratory systems) based on the description of the influence on the respiratory systems, such as bronchitis, bronchopneumonia, and accumulation of fluid in the lungs, in humans (ACGIH (7th, 2001)), and the desciption of the respiratory distress in a ratwith the dosage of the guidance value range of Category 1 (IUCLID (2000)). It was classified in Category 1 (kidney) based on a description of the fatty degenerations of kidney with the dosage of the guidance value range of Category 1 with a rat, and a description of a glomerulonephritis in humans.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	No data available
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	No data available.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）