NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Hydrochloric acid
CAS：7647-01-0

Result：


ID:	567
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Gas (GHS definition)
2	Flammable gases （including chemically unstable gases）	Not classified	-	-	-	-	Non-combustible gas (Hommel, 1991)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not classified	-	-	-	-	UNRTDG No.1050, Class: 2.3, Subsidiary risks Class: 8
5	Gases under pressure	Liquefied gas		Warning	H280: Contains gas under pressure; may explode if heated	P410+P403: Protect from sunlight. Store in a well-ventilated place.	UNRTDG No. 1050, Class: 2.3. "Critical temp: 51 degC" (Hommel, 1991)
6	Flammable liquids	Not applicable	-	-	-	-	Gas (GHS definition)
7	Flammable solids	Not applicable	-	-	-	-	Gas (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Gas (GHS definition)
9	Pyrophoric liquids	Not applicable	-	-	-	-	Gas (GHS definition)
10	Pyrophoric solids	Not applicable	-	-	-	-	Gas (GHS definition)
11	Self-heating substances and mixtures	Not applicable	-	-	-	-	Gas (GHS definition)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Gas (GHS definition)
13	Oxidizing liquids	Not applicable	-	-	-	-	Gas (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Gas (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Gas (GHS definition)
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to gas substances are not available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 3 based on the toxic value of the higher one.(Rat LD50=238 to 277 mg/kg and 700 mg/kg (SIDS (2002)), and higher one is former.)
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on rabbit LD50 >5010mg/kg (SIDS (2002)), it was set as the outside of Category.
1	Acute toxicity （Inhalation: Gases）	Category 3		Danger	H331: Toxic if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was considered as Category 3, based on 1411ppm obtained from the statistical calculations after conversion from rat LC50 = 4.2, 4.7 and 283mg/L/60min (SIDS (2002)). In addition, since it became lower than the lowest value of calculated data, lowest value 4.2mg/L (4-hour product portfolio managements equivalents 1411ppm) of data is adopted.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Rat LC50 = 1.68mg/L / 1h is the aerosol data (SIDS (2002)). It was set as category 2 based on 4-hour value 0.42mg/L of this value.
2	Skin corrosion/irritation	Category 1A-1C		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	There are reports of cases that corrosivity was observed in rabbit skin irritation test with 1 - 4 hour exposure depending on concentration (SIDS (2002)), that stimulation and ulcer accompanied by skin discoloration having occurred on mice and rats with 5-30 minute exposure (SIDS (2002)), and that it also caused mild to serious stimulativeness, sore and burn (SIDS (2002)). Because of what mentioned above, this product was considered to have corrosivity, and it was classified as Category 1A-1C.
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	About damage and the stimulativeness of an eye, it is based on exposure to hydrochloric acid as waters of this product altogether. A serious stimulus, damage, and corrosiveness is indicated for eye in a result of two or more animal (including a rabbit) examinations (SIDS (2002)), and fear of permanent damage or loss of eyesight is indicated to be also in humans (SIDS (2002)).
4	Respiratory sensitization	Category 1		Danger	H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled	P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ...	Since it was listed as one of the chemical substances causing the sensitivity of occupational allergy, created by the specially set-up committee of the Japanese occupational and environmental allergology meeting, it was referred to as Category 1. Still, there is a report that the postexposure bronchial spasms was caused by humans to the cleaning agents which included hydrogen chlorides and that asthmatic symptoms were still caused by slight stimulus one year later (ACGIH (2003)).
4	Skin sensitization	Not classified	-	-	-	-	Adding to the negative result (SIDS (2002)) in Maximization Test of a guinea pigs, and Ear Swelling Test of a mouse, there is a report (SIDS (2002)) that nobody indicated positive reactions in the test applied to 15 humans on 10-14th days after [ induction of sensitization ] , and it put outside of the Category.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data from in vivo tests are found, except for positive results in sex-linked recessive lethal tests using drosophila. Although there are positive results from some in vitro mutagenicity tests, these results are considered as insufficient to be the basis for mutagenesis in human germ cells. So it was decided that the substance "could not be classified".
6	Carcinogenicity	Not classified	-	-	-	-	Based on the classification of Group 3 (1992) by IARC, and A4 (2003) by ACGIH, it was set as the outside of Category. In addition, in carcinogenicity tests of rats or mice, there is no evidence which suggests carcinogenicity (SIDS (2002)), and many human epidemiological studies are also negative in the relation between cancer occurrence and hydrogen chloride exposure (IARC 54 (1992), PATTY (5th, 2001)).
7	Reproductive toxicity	Classification not possible	-	-	-	-	All data are the results of the test in the administration to pregnancy rat or mouse, and there is no bad effect to the development of neonatal animals. However, it was unknown about the effect to reproductive function and reproductive potential in the administration before pregnancy (premating) to parent animals, "it cannot be clasified" since data is insufficient.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system)		Danger	H370: Causes damage to organs (respiratory system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	The symptoms, such as dyspnea, laryngitis, bronchitis, bronchus contraction, and pneumonia, is presented by inhalation exposure in humans, and the upper airway edema, respiratory tract inflammations, necrosis, and a lung blister are reported. (DFGOTvol.6 (1994), PATTY (5th, 2001), IARC 54 (1992), ACGIH (2003)). Moreover, in the animal studies, the toxic effects with morphological injury to lungs and bronchial tubes, such as bronchitis with mucosal necrosis, pulmonary edema, bleeding, thrombus, etc. in the guidance value in Category 1 (ACGIH (2003), SIDS (2002)). It was classified into Category 1 (respiratory systems) based on the above the results in human and animal.
9	Specific target organ toxicity - Repeated exposure	Category 1 (tooth, respiratory system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (tooth, respiratory system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	There are two or more reports that humans who receive repeated exposure complain injury to teeth by erosions ( SIDS and (2002), EHC 21 (1982), DFGOTvol.6 (1994), and PATTY (5th, 2001)), and increased frequency of a chronic bronchitis is also reported. (DFGOTvol.6 (1994)). It was classified as Category 1 (a tooth, respiratory systems) based on these information.
10	Aspiration hazard	Not applicable	-	-	-	-	Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48-hour EC50=0.492mg/L of Crustacea (Daphnia magna), and others (SIDS, 2005).
11	Hazardous to the aquatic environment （Long-term）	Not classified	-	-	-	-	Toxicity factor is considered to be strong acid as aqueous solution, but toxic effect is eased by the buffer action in the environmental water.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）