GHS Classification Result

Chemical Name:Zinc chloride
CAS:7646-85-7

Result:
ID: 566
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible substance (Hommel, 1991)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible substance (Hommel, 1991)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible solid (Hommel, 1991)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (Weiss, 2nd, 1985)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - UNRTDG No. 2331, Class: 8; PGIII
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Melting point: 732degC (ICSC, 2002). Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
SPECIES: Rat ENDPOINT: LD50 VALUE: 1100 mg/kg REFERENCE SOURCE: EU-RAR (2004)
1 Acute toxicity (Dermal) Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 2 based on guinea pig LD50 = 173mg/kg (IUCLID (2000)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 1-5 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
LC50 value decided for the animal is not acquired. But the humans deaths after exposure is reported though an exposure level was unknown (ACGIH (2001), PATTY (5th, 2001)). Therefore, it was set to category 1-5.
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
The dermal surface inflammatory change and ulcers are observed in rabbit skin irritation test (EU-RAR (2004)). Also formations of pustule and vesicles on skin in human patch test were reported (DFGOTvol.19 (2002)). Therefore it was classified as Category 1A-1C.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
An eye has in an accident two reports of the humans who received concentrated zinc chlorides exposure (EU-RAR (2004)). It resulted in cornea cicatrization permanent subsequently to edema, and was set as Category 1 based on description (EU-RAR (2004)) that recovery took 6 - 28 weeks.
4 Respiratory sensitization Classification not possible - - - - The occupational asthmas by soldering flux has been reported by humans (DFGOTvol.19 (2002)) but causes are unknown. since they are also exposed to ammonium chlorides. Therefore, it cannot be classified.
4 Skin sensitization Classification not possible - - - - No data
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
The substance was classified as Category 2. Based on the positive results from the chromosome aberration tests using rats and mice (the in vivo mutagenicity test in somatic cells) (EU-RAR (2004), EHC 221(2001)).
6 Carcinogenicity Classification not possible - - - - Presently there is no institution which has defined the classification Category about the carcinogenicity of the zinc chloride. Each existing long-term animal examination (DFGOT vol.19 (2002)) has defect on protocol as a carcinogenicity tests, and the data which can be utilized about the carcinogenicity of zinc itself is also restricted. EU and U.S. also stated that carcinogenic evaluation has insufficient information (IRIS (2006), EU-RAR (2004)). From the above thing, since data was insufficient, it determined "It cannot be classified."
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based in the reduction of the number of littermates in the dose causing general toxicity of maternal animals (DFGOTvol.19 (2002)), it is classified into the Category 2
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, liver, pancreas) Danger H370: Causes damage to organs (respiratory system, liver, pancreas) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
The artery occlusions in the lungs and fibrosis, cyanosis, ARDS syndrome, etc. are reported in humans after inhalation exposure (ACGIH (7th 2001), PATTY (5th, 2001), and the symptoms includes the irritation to nose, the throat, and the respiratory tracts in addition to nausea, cough, etc. (EU-RAR (2004), ACGIH (7th, 2001)). Furthermore, there is the report of liver damages and pancreatic achylias by oral ingestion (EHC 221 (2001)). It was classified into Category 1 (respiratory system, liver, pancreas) based on these information.
9 Specific target organ toxicity - Repeated exposure Category 1 (lung, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (lung, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In addition to the lung lymphocytic infiltration and the fatty degeneration of the liver, with higher concentrations, high death rates is seen with a mouse by inhalation exposure (DFGOT vol.19 (2002)). It was classified in Category 1 (lungs, liver) by comparing toxic effect concentrations seen in murine lung and liver with the guidance value.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48-hour EC50=0.1mg/L of Crustacea (Daphnia magna) (CERI Hazard Data, 2002).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, and it is a metallic compound, behavior in water is unknown., though less bioaccumulative (BCF=178 (existing chemical safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

MHLW Website (in Japanese Only)


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