GHS Classification Result

Chemical Name：2-Chloroethanol
CAS：107-07-3

Result：
ID: 565
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Flash point: 60degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Not ignite spontaneously on coming into contact with air at normal temperatures
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		SPECIES: Rat ENDPOINT: LD50 VALUE: 71mg/kg REFERENCE SOURCE: ACGIH (2001), RTECS (2004)
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Dermal toxicity LD50 of a rabbit is 67mg/kg (IUCLID (2000)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There are descriptions about LC50 = 0.3mg/L (but exposure time is unknown) (RTECS (2000)) and that death was observed with 1 hour exposure to 7.5ppm (ACGIH (2001)). Soit is supposed to be Category 1.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Results as both being irritating and not irritating is obtained in animal examination (IUCLID (2000)). But PATTY (5th, 2005) states that there is no skin irritation.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		The result which is irritating is obtained in the animal studies (IUCLID (2000)). Although PATTY (5th, 2005) is setting to extremly irritating. But there is no evidence as irreversible, it is set as Category 2A.
4 Respiratory sensitization Classification not possible - - - - There is no data and it cannot be classified..
4 Skin sensitization Not classified - - - - There is proof that there is no skin sensitization by animal studies etc. (PATTY (5th, 2005), IUCLID (2000).).
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There are negative results from the in vivo (multi-generation) reciprocal translocation test in mice, mouse chromosome aberration test and dominant lethal test ((PATTY (5th, 2001)) and from the DNA damage test in rats (IUCLID (2000)), but there are positive results from in vivo chromosome aberration tests in rat bone-marrow (inhalation). There are also positive results from the in vitro (CHO) chromosome aberration test, the sister chromatid exchange test and the Ames test (PATTY (5th, 2001)). So the substance was classified as Category 2.
6 Carcinogenicity Category 1 Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		ACGIH is classified into A4 and there is also data in which carcinogenicity is not indicated in an animal examination. But there is the proof it is carcinogenic to humans in epidemiological data (PATTY (5th, 2005)). So it is set as Category 1.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is effect to embryo in animal experiment even if it is limited result (DFGOT vol. 5 (1993)), it is doubted about reproductive toxicity to human
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, blood system, kidney, liver, respiratory system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (central nervous system, blood system, kidney, liver, respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since the effects to the central nervous system, cardiovascular systems, renal, lung, and liver in human are observed (DFGOT vol.5 (1993)), it is classified into Category 1. Since there is the description which irritates the airway seriously (ICSC (J) (2003)), together with the effect on lung, and the target organ is the respiratory systems. Moreover, since the anaesthetic by inhalations is indicated (DFGOT vol.5 (1993)), it is also classified into Category 3 (anaesthetic).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system), Category 2 (liver, kidney) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (blood system)
H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Though effects on blood systems, liver, kidney were seen (RTECS (2004)), viewed from a guidance value, it is classified in Category 1 for blood system, and Category 2 for liver and kidney .
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 72-hour ErC50=5.6mg/L of algae (Scenedesmus) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 2, since acute toxicity was Category 2, and rapid degradability is unknown, though supposed less bio-accumulative (log Kow=0.03(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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