Chemical Name:Sodium azide (Na(N3))
CAS:26628-22-8
ID: | 562 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not classified | - | - | - | - | Not classified in UNRTDG Class: 1 and Subsidiary risks Class, though containing azido groups. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible | - | - | - | - | Individual literature citations vary about a flammable. The data with tests defined by the United Nations is not found. It is not classified into the United Nations class 4.1. |
8 | Self-reactive substances and mixtures | Type G | - | - | - | - | Not classified in UNRTDG Class: 4.1, but Class: 6.1 (though containing azido groups) |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified | - | - | - | - | Non-pyrophoric at a room temperature |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | No data available on self-heating |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Hydrogen azide is not generated when it melts in neutral waters. |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable | - | - | - | - | Containing no oxygen , chlorine and fluorine. |
15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic substance |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Although there is information that it corrodes aluminum strongly, there is no experimental data of the metal corrosion rate. It is not classified into a class 8 according to UNRTDG, either. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Category 2 | Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Category 2 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 45mg/kg; REFERENCE SOURCE: DFGOT vol.20 (2003) | |
1 | Acute toxicity (Dermal) | Category 1 | Danger | H310: Fatal in contact with skin |
P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment (see ... on this label). P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Since rabbit percutaneous LD50 value was 20mg/kg (ACGIH (2001)), it was set as Category 1. | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | The steam pressure at normal temperature (1 Pa) is less than rat inhalation LC50 (37mg/m3) (RTECS (2004)). |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | It cannot taxonomic according to lack of information. The information on RTECS (2004) is not clear in a chemical exposure forms. (a dust, cracked gas) |
2 | Skin corrosion/irritation | Category 1C | Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
It judged to be "Category 1C" from corrosivity in animal test result and 4 hour contact (DFGOT vol.20 (2003)). | |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Since skin corrosivity was Category 1C, the eye was also set to "category 1." | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | With no sufficient information about causing sensitivity. |
4 | Skin sensitization | Classification not possible | - | - | - | - | With no sufficient information about causing sensitivity. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Although there are positive results from in vitro microbial mutagenicity tests, the in vitro mutagenicity tests in mammalian cells are negative and also there are no data from in vivo tests in mammals. So it was decided that the substance "could not be classified". It is considered that the strong mutagenicity is peculiar to microorganisms and plants. (DFGOT vol.20 (2003)) Category 2, which was based on the in vivo results in muscids, was also suggested in some comments from the experts, but in the end it was concluded that the substance could not be classified. |
6 | Carcinogenicity | Not classified | - | - | - | - | Since it was judged with A4 by ACGIH, it was set as "Outside of Category." |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
8 | Specific target organ toxicity - Single exposure | Category 1 (circulatory system) | Danger | H370: Causes damage to organs (circulatory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
Since there is a large number of examples about hypotension (be used as therapeutic agents) and suspected the side effects to its respiratory organs, digestive organ, etc. So it was classified into "Category 1." | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (circulatory system, liver) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (circulatory system, liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Since increased sensitivity was seen in some patients when it was used for treatment for high blood pressure for humans over a long-term (ACGIH (2001)) , and the effects on the liver was seen with the given dose below 10mg/kg-day in an animal experiments, it was classified in "Category 1." | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 96-hour LC50=0.7mg/L of fishes (Bluegill) (HSDB, 2004). | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (direct measurement (HPLC): 1% (existing chemical safety inspections data)), though supposed less bioaccumulative (log Kow<=0.3 (existing chemical safety inspections data). |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |