GHS Classification Result

Chemical Name:tert-Butyl hydroperoxide
CAS:75-91-2

Result:
ID: 550
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Classification not possible due to lack of data on the kick-off temperature and decomposition energy, though being a peroxide with its oxygen budget calculated at -195. Heating may cause an explosion according to HSDB (2006).
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Because of a lack of data on the flash point. The substance can be classified into Category 2 or 3 with the flash point of <27degC (c.c.) (NFPA (13th, 2002)) and the boiling point of 89degC (decomposition) (Lide (84th, 2003)), and is placed in "Category 2" from the viewpoint of safety.
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Classified as "organic peroxides" though being a peroxide containing chemical groups with explosive properties. Classified into Division 5.2 by the UN Recommendation on the Transport of Dangerous Goods (UN numbers (3103, 3105, 3107, 3109) are given only to those diluted according to their concentrations and proportions of diluents; tert-butyl hydroperoxide in neat liquid is prohibited for transport and thus has no UN number).
9 Pyrophoric liquids Classification not possible - - - - Classification not possible due to lack of data, though heating may cause a fire according to HSDB (2006).
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Classification not possible - - - - Classification not possible due to lack of data, though being organic compounds containing oxygen bound to the elements other than carbon and hydrogen, and classified as a powerful oxidant according to HSDB (2006).
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Type A Danger H240: Heating may cause an explosion P411+P235: Store at temperatures not exceeding ... degC/... degF. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P234: Keep only in original container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P410: Protect from sunlight.
P420: Store away from other materials.
P501: Dispose of contents/container to ...
Type classification is not possible due to lack of data, though organic compounds containing -O-O- structure, with active oxygen quantity calculated at 35.5%, that is, "Organic peroxides." Organic peroxides permitted for transport are assigned general entries by the UN Recommendation on the Transport of Dangerous Goods. As for tert-butyl hydroperoxide, only those diluted are given UN numbers (3103, 3105, 3107, 3109), subclassified into "Type C," "Type D," "Type E" and "Type F" according to their concentrations and proportions of diluents. Since those undiluted are interpreted as "Type A" (prohibited for transport), tert-butyl hydroperoxide (in neat liquid) is classified as "Type A" by GHS classification. Those diluted are assigned to Division 5.2 (UN#3103 Organic peroxides Type C (liquid), UN#3105 Organic peroxides Type D (liquid), UN#3107 Organic peroxides Type E (liquid) and UN#3109 Organic peroxides Type F (liquid )) by the UN Recommendation on the Transport of Dangerous Goods.
16 Corrosive to metals Classification not possible - - - - No data available. Under the UN Recommendation on the Transport of Dangerous Goods, those diluted substances classified as "Organic peroxides" need to be labeled with the subsidiary risk label of "Corrosive Substances." However, the category includes skin corrosivity, and it is unclear whether the substance is classified as "metal" corrosive (UN numbers of those in solution: UN#3103 Organic peroxides Type C (liquid), UN#3105 Organic peroxides Type D (liquid), UN#3107 Organic peroxides Type E (liquid) and UN#3109 Organic peroxides Type F (liquid)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 560mg/kg (SIDS (1995)).
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the LD50 value of 470mg/kg representing the lower of the two testing data, rabbit LD50 (dermal route) of 628mg/kg (SIDS (1995)) and rat LD50 (dermal route) of 470mg/kg (PATTY (4th, 1999)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LC50 (inhalation of vapour) value of 502ppm (PATTY (4th, 1999)) was lower than 90% of the saturated vapour concentration (27,000ppm) under a saturated vapour pressure of 2.7kPa (20degC), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description in the report on rat skin irritation tests (PATTY (4th, 1999)): "Causes very strong irritation." Although classified into Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Based on the description in the report on rat eye irritation tests (PATTY (4th, 1999)): "Causes very strong irritation." Also based on the description in ICSC (1999) of human health effects: "redness, pains and deep burn." The substance is thus considered corrosive to the eye.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on negative and positive data on multi-generation mutagenicity tests (dominant lethal tests) and somatic cell mutagenicity tests in vivo (chromosome aberration tests), and the absence of data on germ cell mutagenicity tests in vivo, described in SIDS (1995), DFGOT Vol. 3 (1992) and NTP DB (Access on June, 2006). The results of dominant lethal tests were not based on the sound knowledge, whereas the positive data on chromosome aberration tests in vivo were considered not to be definitive. However, all the in vitro tests (Ames assay, chromosome aberration assay, mouse lymphoma) were positive for mutagenicity, and therefore the substance is classified into Category 2.
6 Carcinogenicity Classification not possible - - - - Insufficient data available
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on parental reproduction and pup development in combined studies and teratogenicity studies, described in SIDS (1995).
8 Specific target organ toxicity - Single exposure Category 2 (nervous system, blood system, respiratory system), Category 3 (narcotic effects) Warning H371: May cause damage to organs (nervous system, blood system, respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects)
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on the evidence from animal studies: "clinical signs including hypoactivity and lacrimation...loss of righting reflex...signs of hematuria" (PATTY (4th, 1999)) , "hypoactivity...loss of righting reflex, lacrimation...hematuria" (IUCLID (1999)), "methemoglobinemia or carboxyhemoglobin," "cyanosis" (RTECS (2006)), "decreased respiratory rate and apnea" (IUCLID (1999)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2 (nervous system, blood system) and Category 1 (respiratory organs). However, the referenced study for the respiratory effects has a priority rating of 2, which does not meet the criteria for 1b (3) specified in the "Technical Guideline for GHS Health Hazard Classification," therefore these are classified into Category 2.
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney), Category 2 (blood system) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (kidney)
H373: May cause damage to organs through prolonged or repeated exposure (blood system)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including "reticulocytopenia, increased bilirubin level, and nephrosis" (SIDS (1995)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (kidneys) and Category 2 (blood system).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 3 day ErC50=2.1mg/L of the algae (Selenastrum) (IUCLID, 2000).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=1.8(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

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