NITE - Chemical Management Field

GHS Classification Result

Chemical Name：m-Nitroaniline
CAS：99-09-2

Result：


ID:	546
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not classified	-	-	-	-	Classification not possible due to lack of data, though the substance contains nitro groups with its oxygen budget calculated at -151. According to Bretherick (J) (5th, 1998), the kick-off temperature is 213degC, whereas the decomposition energy is 1.882kJ/g (280-380degC), which can be classified as "Explosives." Classified into Division 6.1 (UN#1661 (o-, m-, p-)) (UN Recommendation on the Transport of Dangerous Goods).
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
6	Flammable liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
7	Flammable solids	Not classified	-	-	-	-	Insufficient data available, though classified as flammable(HSDB (2006)) and the powder or granules, when mixed with the air, may cause dust explosion (ICSC (2004)) . Classified into Division 6.1 (UN#1661(o-, m-, p-)) (UN Recommendation on the Transport of Dangerous Goods).
8	Self-reactive substances and mixtures	Not classified	-	-	-	-	Not classified with the kick-off temperature of 213degC (Bretherick (J) (5th, 1998)), though the substance contains nitro groups with explosive properties. Classified into Division 6.1 (UN#1661 (o-, m-, p-)) (UN Recommendation on the Transport of Dangerous Goods).
9	Pyrophoric liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
10	Pyrophoric solids	Not classified	-	-	-	-	Classified into Division 6.1 (UN#1661 (o-, m-, p-)) (UN Recommendation on the Transport of Dangerous Goods).
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available (melting point: 114degC (ICSC, 2002), test temperature: 140degC).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
14	Oxidizing solids	Not classified	-	-	-	-	No data available, though being organic compounds containing oxygen bound to the elements other than carbon and hydrogen. Classified into Division 6.1 (UN#1661 (o-, m-, p-)) (UN Recommendation on the Transport of Dangerous Goods).
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 535mg/kg representing the lower of the two testing data, 535mg/kg and 540mg/kg (SIDS (1995)).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Some human epidemiological studies provide evidence of skin irritation potential (PATTY (4th, 1999)): "The substance is rapidly absorbed through intact skin, and irritates the skin, eye and mucous membranes." However, classification is not possible since the severity of the effects is not presented.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	Some human epidemiological studies provide evidence of eye irritation potential (PATTY (4th, 1999)): "The substance is rapidly absorbed through intact skin, causing irritation of the skin, eye and mucous membranes." However, classification is not possible since the severity of the effects is not presented.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in Report by the Ministry of Health, Labour and Welfare (1994), NTP DB (Access on June, 2006) and SIDS (1995).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the indication of a potential of parturition or lactation disorder at doses inducing parental toxicity, described in Report by the Ministry of Health, Labour and Welfare (1994).
8	Specific target organ toxicity - Single exposure	Category 2 (blood system)		Warning	H371: May cause damage to organs (blood system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the human evidence: "Acute exposure can cause methemoglobinemia, cyanosis" (HSDB (2003)). Also based on the evidence from animal studies including "increased methemoglobin and sulfhemoglobin levels in blood" (HSDB (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. The priority rating for the referenced study for human effects is 2.
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, blood system, testis)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver, blood system, testis)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the human evidence: "Chronic exposure can cause liver damage" (HSDB (2003)), "may adversely affect the blood system, forming methemoglobin" (ICSC (J) (2001)). Also based on the evidence from animal studies including "cyanosis, methemoglobinemia, testicular atrophy and hepatocyte swelling" (Report by the Ministry of Health, Labour and Welfare (1994)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 3 from 24 hours EC50=36mg/L of the crustacea (Daphnia magna) (SIDS, 1995).
11	Hazardous to the aquatic environment （Long-term）	Category 3	-	-	H412: Harmful to aquatic life with long lasting effects	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Although acute toxicity was Category 3 and the bio-accumulation potential was low (BCF=3(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 3.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）