GHS Classification Result

Chemical Name:Iron carbonyl
CAS:13463-40-6

Result:
ID: 542
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
The flash point is -15degC (ICSC (2004)) and the boiling point is 103degC, which is classified into Category 2. Classified into Class 3 and Division 6.1 (UN#1994) (UN Recommendation on the Transport of Dangerous Goods).
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not classified based on the "Technical Guideline of GHS Classification of Physical Hazard" (Mar.10, 2006) since the substance is Classified into Class 3 and Division 6.1 (UN#1994) by the UN Recommendation on the Transport of Dangerous Goods, though it has the flash point of 50degC (ICSC (2004)) and may be pyrophoric when in contact with air, which could be classified into "Category 1."
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (insoluble, ICSC (2004))
13 Oxidizing liquids Not classified - - - - Classified as a powerful reducing agent by ICSC (2004), though being inorganic compounds containing oxygen
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Not classified - - - - Classified into Class 3 and Division 6.1 (UN#1994) (UN Recommendation on the Transport of Dangerous Goods).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 25mg/kg representing the lower of the two testing data, 25mg/kg (RTECS (2006)) and 40mg/kg (IUCLID (2000)).
1 Acute toxicity (Dermal) Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the LD50 value of 105mg/kg calculated from the testing data of rabbit LD50 (dermal route) of 56mg/kg (RTECS (2006)), 240mg/kg, 250mg/kg and 170mg/kg (males) (IUCLID (2000)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LC50 (4 hours) value of 0.32mg/L (equivalent to 40ppm), calculated from the testing data of rat LC50 (inhalation of vapour) of 0.91mg/L (30 min) (equivalent to 115ppm) (ATSDR (2001)), was lower than 90% of the saturated vapour concentration (46,000ppm) under a saturated vapour pressure of 35torr (25degC), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Based on the description in the report on rabbit skin irritation tests (4 hour application) performed in accordance with OECD Test Guideline (IUCLID (2000)): "Not irritating."
3 Serious eye damage/eye irritation Not classified - - - - Based on the description in the report on rabbit eye irritation tests performed in accordance with OECD Test Guideline 405 (IUCLID (2000)): "Not irritating."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to the insufficiency of data (no data available on in vivo mutagenicity/genotoxicity tests)
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, nervous system, cardiovascular system), Category 2 (liver, kidney) Danger
Warning
H370: Causes damage to organs (respiratory system, nervous system, cardiovascular system)
H371: May cause damage to organs (liver, kidney)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
Based on the human evidence including "liver and kidney damage; central nervous system degeneration" (HSDB (2005)), "pathological lesions including hepatization of the lung, vascular disorder and central nervous system degeneration" (PATTY (4th, 1999)), and the evidence from animal studies: "clinical symptoms following exposure include respiratory depression, cyanosis, tremor and motor paralysis" (ACGIH (7th, 2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. Since the referenced studies for the effects on human liver and kidneys are assigned a priority rating of 2, these effects are classified into Category 2.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, blood system, respiratory system) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, blood system, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the description in ICSC (J) (1995): "The substance adversely affects the liver, inducing hepatic dysfunction." Also based on the evidence from animal studies: "Treatment-related histopathological changes occurred in the lung; a slight but significant increase in carboxyhemoglobin was detected" (IUCLID (2000)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. However, the substance is classified into Category 2 since the priority rating of referenced studies is 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since it was suggested that relevant toxicity is not indicated within the water solubility (100mg/L (IUCLID (2000)) of this substance in spite of 48 hours EC50=130mg/L and EC0=62.5mg/L of the crustacea (Daphnia magna) (IUCLID (2000)), it was classified into Not classified.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since it was not water-insolubility (the water-solubility =100mg/L (IUCLID, 2000)), and acute toxicity was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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