GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1,3-Dibromopropane
CAS：109-64-8
Result：
| ID: | 539 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
The flash point is 54degC (Dean (15th, 1999)), which is classified into "Category 3." |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine or chlorine |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on in vivo mutagenicity/genotoxicity tests and no positive data on in vitro mutagenicity tests (several indices). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
|
Danger | H370: Causes damage to organs (nervous system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "salivation, reduced locomotor activity, abnormal gait, prone position and lateral position" (Report by the Ministry of Health, Labour and Welfare (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (blood system, liver) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (blood system, liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "decreases in the red blood cell counts, hemoglobin, hematocrit, and lymphocyte fraction ratio and increases in the reticulocyte ratio and segmented neutrophil fraction ratio; increases in ASAT, ALAT, gamma-GTP, albumin, total cholesterol, phospholipids," (Report by the Ministry of Health, Labour and Welfare (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 96 hours LC50=7.8mg/L of the fish (Oryzias Latipest) (MOE eco-toxicity tests of chemicals, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |
|
- | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity was Category 2 and the bio-accumulation potential was low (log Kow=2.37(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 48%(Existing Chemical Safety Inspections Data)), it was classified into Category 2. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |