GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Tris(dimethylphenyl) phosphate
CAS：25155-23-1
Result：
| ID: | 513 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 6 | Flammable liquids | Not classified | - | - | - | - | The flash point is 232degC (Hawley (14th, 2001)) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | The substance is primarily used as incombustible material, plastics and hydraulic fluids, and therefore considered not to be pyrophoric when in contact with air at ordinary temperatures (HSDB, 2006). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (water solubility: 0.002wt% (85degC), Hawley (14th, 2001)) |
| 13 | Oxidizing liquids | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on the rat LD50 (oral route) values of >25,000mg/kg (CERI Hazard Data 2001-28 (2002)) and >20,000mg/kg (CERI-NITE Hazard Assessment No.24 (2005)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | Insufficient data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Based on the description in the report on rabbit skin irritation tests (CERI-NITE Hazard Assessment No.24 (2005)): "Slight erythematous responses persisted by 72 hours." |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the description in the report on rabbit eye irritation tests (CERI-NITE Hazard Assessment No.24 (2005)): "At 1 hour, with and without rinsing, treated animals experienced mild to moderate irritation with conjunctival edema" that was completely reversible within 24 hours. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on in vivo mutagenicity tests and no positive data on in vitro mutagenicity tests (several indices), described in NTP DB (Access on May 2006), CERI-NITE Hazard Assessment No.24 (2005) and CERI Hazard Data 2001-28 (2002). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system) |
|
Warning | H371: May cause damage to organs (nervous system) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies: "ataxia and neuropathological changes, suggesting that tris(dimethylphenyl) phosphate induces neurotoxicity" (CERI-NITE Hazard Assessment No.24 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Insufficient data available |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since a potential that relevant toxicity was indicated in the water solubility (0.89mg/L (PHYSPROP Database (2005)) of this substance could not be denied from 48 hours EC50=5.9mg/L of the crustacea (Daphnia magna) (MOE Eco-Toxicity Tests of Chemicals (1997)), it was classified into Category 1. |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity is Category 1 and bio-accumulation is low (BCF=466.4(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |