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GHS Classification Result

Chemical Name：Methyl 3-chloro-5-(4,6-dimethoxy-2-pyrimidinylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate
CAS：100784-20-1

Result：


ID:	504
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
6	Flammable liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
7	Flammable solids	Classification not possible	-	-	-	-	Classification not possible due to lack of data
8	Self-reactive substances and mixtures	Classification not possible	-	-	-	-	Classification not possible due to lack of data, though being a sulfonyl compound containing chemical groups with self-reactive properties.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
10	Pyrophoric solids	Classification not possible	-	-	-	-	Classification not possible due to lack of data
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Classification not possible due to lack of data
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
14	Oxidizing solids	Classification not possible	-	-	-	-	Cannot be classified though being organic compounds containing oxygen bound to elements other than carbon and hydrogen
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 175.5-177.2degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 (oral route) value of 7,758mg/kg (Agricultural Chemical Registration Data (1990)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (1990)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Based on the rat LC50 (inhalation route) value of >6.0mg/L (4 hours), together with the absence of mortality (Agricultural Chemical Registration Data (1990)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on no evidence of irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1990)).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	In rabbit eye irritation tests, the treated animals exhibited a mean Draize score of 0.7, and were fully recovered (Agricultural Chemical Registration Data (1990)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	No skin sensitizing potential was found in guinea pig sensitization tests employing the Maximization method (Agricultural Chemical Registration Data (1990)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data in in vitro studies (chromosome aberration tests, reverse mutation tests and DNA repair tests) and mouse in vivo micronucleus tests (Agricultural Chemical Registration Data (1990, 1991)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related increase in tumor incidence observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration Data (1992)).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproduction or offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1990, 1991, 1993)).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Insufficient data available
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Insufficient data available
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 14 days EC50=0.042ppb of the aquatic plant (Lemna Gibba) (AQUIRE, 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=-0.02(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）