GHS Classification Result

Chemical Name:(Z)-2'-methylacetophenone 4,6-dimethyl-2-pyrimidinylhydrazone
CAS:89269-64-7

Result:
ID: 503
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Being a hydrazine compound, the substance contains chemical groups with explosive properties, but its oxygen budget is calculated at -245, that is "Not classified."
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though being a hydrazine compound containing chemical groups with explosive properties.
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat at 60degC for a month (Agricultural Chemical Registration Data)
11 Self-heating substances and mixtures Classification not possible - - - - Classification not possible due to lack of data
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 173.9degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 642mg/kg (Agricultural Chemical Registration Data (1991)).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (1991)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >3.8mg/L (4 hours) (Agricultural Chemical Registration Data (1991)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the evidence of mild irritation with a Draize score of 1.6, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1991)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on the evidence of reversible irritation, with effects persisting for up to day 16, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1991)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - No skin sensitizing potential was found in guinea pig sensitization tests employing the Buehler method (Agricultural Chemical Registration Data (1991)).
5 Germ cell mutagenicity Not classified - - - - Based on negative data in in vitro studies (chromosome aberration tests, reverse mutation tests and DNA repair tests) and mouse in vivo micronucleus tests (Agricultural Chemical Registration Data (1991, 1994)).
6 Carcinogenicity Classification not possible - - - - Classification not possible in the absence of existing classification, though tumor formation was found in rat carcinogenicity studies (Agricultural Chemical Registration Data (1991)).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on reproduction or offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1991)).
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including "reduced locomotor activity," "abnormal gait," "muscle flaccidity," "convulsions," and "tremors" (Agricultural Chemical Registration Data (1991)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Insufficient data available.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 48 hours EC50=6.2mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2000).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity was Category 2 and the bio-accumulation potential was low (log Kow=2.98(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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