GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Poly(oxyethylene) nonylphenyl ether
CAS：9016-45-9
Result：
| ID: | 494 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition (EO9.5). |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition (EO9.5). |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition (EO9.5). |
| 6 | Flammable liquids | Not classified (EO9.5) | - | - | - | - | The flash point is 282degC (CERI-NITE Hazard Assessment (2004)) (EO9.5). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition (EO9.5). |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
| 9 | Pyrophoric liquids | Not classified (EO9.5) | - | - | - | - | Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is used as commercial detergents (EO9.5, CERI-NITE Hazard Assessment (2004)) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition (EO9.5). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test method applicable to liquid substances are not available (test temperature: 140degC). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not fluorine and chlorine), with oxygen bound to carbon and hydrogen (but not to other elements) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition (EO9.5). |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | The test compounds with different EO chain lengths yielded substantially different toxic effect values: 1,300mg/kg (EO10), >15,900mg/kg (EO20) (CERI-NITE Hazard Assessment No.96 (2004)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | The test compounds with different EO chain lengths yielded substantially different toxic effect values: 1,800mg/kg (EO7), >10,000mg/kg (EO40) (CERI-NITE Hazard Assessment No.96 (2004)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is a liquid according to the GHS criteria and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Based on the description in the report on rabbit skin irritation tests (exposure duration unknown) (CERI-NITE Hazard Assessment No.96 (2004)): Application of the undiluted test compound (EO2-9) produced "moderate to severe irritation" of the skin. |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on the description in the report on rabbit eye irritation tests (CERI-NITE Hazard Assessment No.96 (2004)): Instillation of the undiluted test compound (EO2-15) resulted in "moderate to severe irritation" of the eye. The substance is thus considered "strongly irritating." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | According to the description in CERI-NITE Hazard Assessment No.96 (2004), a skin sensitization study with the test compound (EO6) showed no indication of sensitization in guinea pigs. However, classification is not possible due to lack of sufficient data because only one set of data showing "negative" is available. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on negative data in multi-generation mutagenicity tests (dominant lethal tests) and somatic cell mutagenicity tests in vivo (micronucleus tests), and the absence of data in in vivo germ cell mutagenicity tests, described in CERI-NITE Hazard Assessment No.96 (2004) and NITE Initial Risk Assessment No.96 (2005). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible based on a judgment made by experts in the absence of existing classification, though CERI-NITE Hazard Assessment No.96 (2004) and NITE Initial Risk Assessment No.96 (2005) present some toxicity data. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence of reduced female fertility and a decreased number of embryos, described in CERI-NITE Hazard Assessment No.96 (2004) and NITE Initial Risk Assessment No.96 (2005) (though no data are available regarding parental toxicity). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | Classification not possible due to the insufficiency of data. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver, cardiovascular system) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (liver, cardiovascular system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "an increase in relative liver weights in females; histopathological examination revealed hepatocellular fatty changes in both sexes," "microscopic examination showed focal necrosis of myocardium" (NITE Initial Risk Assessment No.96 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 (NPE1.5, NPE9-10), Not classified (NPE30) |
|
Warning | H400: Very toxic to aquatic life (NPE1.5, NPE9-10) |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
NPE1.5: It was classified into Category 1 from 48 hours LC50=0.11mg/L of the crustacea (Mysid Shrimp) (CERI/NITE Hazard Assessment Report (2005)). NPE9-10: It was classified into Category 1 from 96 hours LC50=1.0mg/L of the fish (Salmo trutta) (CERI/NITE Hazard Assessment Report (2005)). NPE30: It was classified into Not classified from 96 hours LC50>1000mg/L of the fish (Bluegill) (CERI/NITE Hazard Assessment Report (2005)). [NOTE] Since the toxicity of polyoxyethylene nonylphenyl ether increases as ethylene oxide chain length decreases, it pointed to the category of several ethylene oxide chain length. In addition, polyoxyethylene nonylphenyl ether described as NPEn (n: mole numbers of added ethylene oxide.). |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible (NPE1.5, NPE9-10), Not classified (NPE30) | - | - | - | - | NPE1.5, NPE9-10: Since degradability and bioaccumulation depend on mole numbers of added ethylene oxide and test condition and there was no data about each chain length, classification is not possible. NP30: Since it was not poorly water-soluble (the water solubility increases as mole numbers of ethylene oxide increase, and it can be soluble in the water if mole numbers become more than 7 (CERI/NITE Hazard Assessment Report (2005))), and acute toxicity was low, it was classified into Not classified. [NOTE] Since the toxicity of polyoxyethylene nonylphenyl ether increases as ethylene oxide chain length decreases, it pointed to the category of several ethylene oxide chain length. In addition, polyoxyethylene nonylphenyl ether described as NPEn (n: mole numbers of added ethylene oxide.). |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |