NITE - Chemical Management Field

GHS Classification Result

Chemical Name：2-(2-benzothiazolyloxy)-N-methylacetanilide
CAS：73250-68-7

Result：


ID:	489
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
6	Flammable liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
7	Flammable solids	Classification not possible	-	-	-	-	No data available
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Containing no chemical groups with explosive or self-reactive properties
9	Pyrophoric liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
10	Pyrophoric solids	Classification not possible	-	-	-	-	No data available
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test method applicable to liquid substances are not available (melting point: 134.8degC (Merck (13th, 2001)), test temperature: 140degC).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
14	Oxidizing solids	Not applicable	-	-	-	-	Organic compounds containing oxygen (but not fluorine and chlorine), with oxygen bound to carbon and hydrogen (but not to other elements)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 134.8degC, Merck (13th, 2001)).

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 (oral route) value of >5,000mg/kg (RTECS (2006) and IUCLID (2000)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of > 5,000mg/kg (RTECS (2006) and IUCLID (2000)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Insufficient data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Insufficient data available
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No evidence of irritation was observed in a rabbit skin irritation test (though the results are not those of 4 hour application) (IUCLID (2000)). Although the substance could be "Not classified" based solely on the results of the above study, "Classification not possible" should be appropriate since the study is assigned a priority rating of 2 and no other data are available to provide additional or supporting evidence.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No evidence of irritation was observed in a rabbit eye irritation test (IUCLID (2000)). Although the substance could be "Not classified" based solely on the results of the above study, "Classification not possible" should be appropriate since the study is assigned a priority rating of 2 and no other data are available to provide additional or supporting evidence.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Classification not possible due to the insufficiency of data (details are not available on the protocols of in vivo studies).
6	Carcinogenicity	Classification not possible	-	-	-	-	Classification not possible based on a judgment made by experts in the absence of existing classification, though IUCLID (2000) presents some toxicity data.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence of adverse effects on offspring development (fetal death and muscle skeletal anomalies), described in IUCLID (2000) and RTECS (2006) (though no data are available regarding parental toxicity).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Classification not possible due to the insufficiency of data.
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system, kidney)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (blood system, kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "normocytic anemia" (RTECS (1996)), "kidney effects including renal failure and renal tubular necrosis" (RTECS (1996)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from ErC50=0.226mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=3.23(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）