GHS Classification Result

Chemical Name：Beryllium oxide
CAS：1304-56-9

Result：
ID: 485
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC, 2004)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-flammable (ICSC, 2004)
11 Self-heating substances and mixtures Not classified - - - - Non-flammable (ICSC, 2004)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (insoluble (20degC), ICSC (2004))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data, though being inorganic compounds containing oxygen
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description in the report on epidemiological studies of human exposure (HSDB (2006)): "The substance burns the skin and eye." Also based on the evidence of "redness" (ICSC (2000)). The substance is thus considered irritating to the skin.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on epidemiological studies of human exposure (HSDB (2006)): "The substance burns the skin and eye." Also based on the evidence of "redness and pain" (ICSC (2000)). The substance is thus considered irritating to the eye.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to the insufficiency of data (no data available on in vivo mutagenicity/genotoxicity tests) As for the reproductive mutagenicity of beryllium compounds, refer to "ID487, Beryllium Sulfate, CAS: 7787-56-6."
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category K (Beryllium (CAS 7440-41-7) and Beryllium Compounds) by NTP (2005) and Category 1 (BERYLLIUM AND BERYLLIUM COMPOUNDS) by IARC (1993).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of fetal malformation or death, described in ATSDR (2002) and CICAD 32 (2001) (though no data are available on parental toxicity).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies: "examinations revealed inflammation characterized by increased interstitial mononuclear cells and a thickening of the alveolar septa....indicates cellular damage to the type II cells or the alveolar epithelium." (ATSDR (2002)), "some granulomatous lesions were seen in the rat lung" (EHC 106 (1990)).The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, blood system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence: "The five workers had abnormal chest x-rays, noncaseating granulomas, pulmonary fibrosis," "Five of these workers had consistently abnormal BeLPT results and were diagnosed with chronic beryllium disease based on the observation of granulomas." (ATSDR (2002)), "it became evident that the acute respiratory effects could be caused by inhalation of beryllium fluoride, sulfate, chloride, oxide, or hydroxide, and metallic dust" (EHC 106 (1990)), "diagnosed with chronic beryllium disease based on observation of granulomas in lung biopsy samples," "The CBD cases had the classic signs of CBD, including radiologically visible hilar adenopathy, noncaseating granuloma and pulmonary fibrosis in biopsy samples, and decreased carbon monoxide diffusing capacity (DLCO)" (IRIS (1998)). Also based on the evidence from animal studies: "vascular congestion, emphysema, and pneumonitis were observed (slight clinical symptoms included...macrocytic anemia," "inflammation and fibrosis of the lung" (ATSDR (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ... 		"Inhalation of dust or fume may cause chemical pneumonia" (ICSC (J) (2000)). According to the technical guideline, "metal dust of beryllium fluoride may produce chemical pneumonia following inhalation exposure etc. In the ICSC card, under the heading of 'important data,' it says 'inhalation of dust/fume may cause chemical pneumonia.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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