GHS Classification Result

Chemical Name:Beryllium fluoride
CAS:7787-49-7

Result:
ID: 484
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (HSDB, 2006)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-flammable (HSDB, 2006)
11 Self-heating substances and mixtures Not classified - - - - Non-flammable (HSDB, 2006)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (highly soluble in water, ICSC (2004))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data, though being inorganic compounds containing fluorine.
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the LD50 value of 98.1 mg BeF2/kg calculated from the testing data of rat LD50 (oral route) of 18.8 mg beryllium/kg (DFGOT Vol.21 (2005)).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the human epidemiological evidence of "skin edema following exposure to dust" (ATSDR (2002), "redness and pain" (ICSC (2000)) and "irritation" (HSDB (2006)), and the description in ICSC (2000): Short-term exposure produces "severe irritation of the skin." The substance is thus considered a severe skin irritant.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on the human epidemiological evidence of "redness, pain and blurred vision" (ICSC (2000)), "irritation" (HSDB (2006)), and the description in ICSC (2000): Short term exposure produces "severe irritation of the eye." The substance is thus considered a severe eye irritant.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the evidence of "delayed dermal reactions" from guinea pig skin sensitization tests (ATSDR (2002)). Also based on the description in the report on sensitization tests in guinea pigs (DFGOT Vol.21 (2005)): "26 of 33 Harley guinea pigs, five of 10 Pirbright guinea pigs and eight of 11 inbred guinea pigs demonstrated positive responses." Also based on the human epidemiological evidence: "All 13 patients who had beryllium fluoride-induced dermatitis showed positive responses in patch tests."
5 Germ cell mutagenicity Classification not possible - - - - No data available As for the reproductive mutagenicity of beryllium compounds and inorganic fluorides, refer to "ID487, Beryllium Sulfate, CAS: 7787-56-6" and "ID479, Sodium Fluoride, CAS: 7681-49-4" respectively.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Category K (Beryllium (CAS 7440-41-7) and Beryllium Compounds) by NTP (2005) and Category 1 (BERYLLIUM AND BERYLLIUM COMPOUNDS) by IARC (1993).
7 Reproductive toxicity Classification not possible - - - - Insufficient data available
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the human evidence: "Beryllium fluoride severely irritates the eye, skin and respiratory tract; may induce chemical pneumonia following inhalation of dust or fume" (ICSC (J) (2000)). Refer to the GHS classification of fluoride compounds, in particular "Hydrogen Fluoride" since "the severity of the effects was more notable with beryllium fluoride than with beryllium sulfate or beryllium hydrogen phosphate, partly due to the fluoride component which may form hydrofluoric acid in the lung as beryllium fluoride dissociates" (ATSDR (2002)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, kidney, adrenal gland, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, adrenal gland, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence: "The acute respiratory effects could be caused by inhalation of beryllium fluoride etc." (EHC 106 (1990)). Also based on the evidence from animal studies: "Histology revealed pleuritis, congestion, emphysema, consolidation, and edema of the lung; glomerular degeneration in the kidneys; marked hypoplasia and hypotrophy of the adrenal gland; hepatocyte degeneration" (ATSDR (2002)), "caused pulmonary lesions" (EHC 106 (1990)).The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Category 2 Warning H305: May be harmful if swallowed and enters airways P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331: Do NOT induce vomiting.
P405: Store locked up.
P501: Dispose of contents/container to ...
"Inhalation of dust or fume may cause chemical pneumonia" (ICSC (J) (2000)). According to the technical guideline, "metal dust of beryllium fluoride may produce chemical pneumonia following inhalation exposure etc. In the ICSC card, under the heading of 'important data,' it says 'inhalation of dust/fume may cause chemical pneumonia,' and the following chemicals are listed as examples" (ICSC (J) (2000)). The present substance is assumed to be included in the list and thus classified into Category 2 for "Aspiration hazard."

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

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