Chemical Name：Polymer of N,N'-propylenebis(dithiocarbamic acid) and zinc
CAS：12071-83-9

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 (oral route) value of >2,500mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (1968)).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	Classification cannot be determined, though the available rat dermal study reported the LD50 value of >1,000mg/kg (Agricultural Chemical Registration Data (1968)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >0.557mg/L (4 hours) (Agricultural Chemical Registration Data (1968)).
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	The substance was "not irritating" in rabbit skin irritation tests, but no details (including exposure duration) were given (IUCLID (2000)).
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	The substance was "not irritating" in rabbit eye irritation tests, but no details (including exposure duration) were given (IUCLID (2000)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Based on positive results in guinea pig skin sensitization tests employing the Draize method (Agricultural Chemical Registration Data (1989)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data in in vitro reverse mutation tests, in vivo micronucleus tests on mouse bone marrow cells and mouse in vivo dominant lethal tests, though in vitro chromosome aberration tests gave positive results (Agricultural Chemical Registration Data (1989)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related increase in tumor incidence observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration Data (1978, 1989)).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence of reduced litter size at doses causing parental toxicity in rat 3-generation reproduction tests. Also based on the evidence of runting syndrome, deformed long bones of the limbs, increased postimplantation loss, and a decreased number of live fetuses at parentally toxic doses observed in teratogenicity studies in rats and rabbits (Agricultural Chemical Registration Data (1978, 1989)).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Insufficient data available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Insufficient data available.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 72 hours ErC50=0.022mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=2.06(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1.