NITE - Chemical Management Field

GHS Classification Result

Chemical Name：N-(tert-Butyl)-2-benzothiazolesulfenamide
CAS：95-31-8

Result：


ID:	478
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
6	Flammable liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
7	Flammable solids	Classification not possible	-	-	-	-	No data available
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Containing no chemical groups with explosive or self-reactive properties
9	Pyrophoric liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
10	Pyrophoric solids	Classification not possible	-	-	-	-	No data available
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available (melting point: 108degC (Lide, 84th, 2003), test temperature: 140degC).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
14	Oxidizing solids	Not applicable	-	-	-	-	Organic compounds containing no oxygen, fluorine and chlorine
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Because the rat LD50 (oral route) value of >2,000mg/kg representing the lower of the two testing data, >2,000mg/kg (SIDS (2004)) and >6,310mg/kg (CERI Hazard Data 2001-18 (2002)), is in accordance with OECD TG423, and no evidence of deaths or toxic effects was observed.
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rabbit LD50 (dermal route) value of >7,940mg/kg (SIDS (2004)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on the description in the report on rabbit skin irritation tests evaluated according to the Draize scheme (SIDS (2004)): "It can be concluded that the substance is essentially non irritating to the human skin, though only slight irritation was observed." Also based on the description in CERI-NITE Hazard Assessment No.22 (2005): "There is no evidence of skin irritation."
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Based on the description in the report on rabbit eye irritation tests (SIDS (2004)): "It can be concluded that the substance is essentially non irritating to the eye, though mild irritation was observed."
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Based on three epidemiological case reports that provide the evidence of skin sensitization in humans (CERI-NITE Hazard Assessment No.22 (2005)). Also based on the description in the report on guinea pig skin sensitization tests performed according to Buehler Method (SIDS (2005)): "Skin sensitization: positive."
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in NITE Initial Risk Assessment No.22 (2005), CERI Hazard Data 2001-18 (1997), CERI-NITE Hazard Assessment No.22 (2005) and SIDS (2004).
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproductive organs of parental animals and on the offspring in repeated dose toxicity and reproductive toxicity combined studies, described in NITE Initial Risk Assessment No.22 (2005), CERI-NITE Hazard Assessment No.22 (2005) and SIDS (2004).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Insufficient data available
9	Specific target organ toxicity - Repeated exposure	Category 2 (kidney, blood system, liver)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (kidney, blood system, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "vacuolar degeneration of the proximal renal tubules and hemolysis" (Report by the Ministry of Health, Labour and Welfare (1997)), "localized or multiple focal necrosis in the liver" (NITE Initial Risk Assessment No.22 (2005)), "histopathological changes in the liver were observed in the highest dose group" (SIDS (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 72 hours ErC50=0.071mg/L of the algae (Selenastrum) (SIDS, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity is Category 1 and bio-accumulation is low (BCF<8 (2-mercaptobenzothiazole), BCF=51(di(benzothiazol-2-yl)persulfide), BCF=16 (tert-butylamine) and BCF=7.5 (benzothiazole)(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）