GHS Classification Result

Chemical Name：Di-n-octyl phthalate
CAS：117-84-0

Result：
ID: 472
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - The flash point is 215degC (open cup flash test) (NFPA (13th, 2002))
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 390degC (NFPA, 13th, 2002)).
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the LD50 value of 32,100mg/kg calculated from the testing data of rat LD50 (oral route) of 30,000mg/kg, 53,700mg/kg (CERI Hazard Data 2001-63 (2002)), 47,000mg/kg (MOE Risk Assessment vol. 4 (2005)) and 34,000mg/kg (PATTY (4th, 1999)).
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the guinea pig LD50 (dermal route) value of 4,890mg/kg (CERI Hazard Data 2001-63 (2002)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - The results of human patch tests suggest no evidence of skin irritation (CERI Hazard Data 2001-63 (2002)), whereas MOE Risk Assessment vol. 4 (2005) provides some evidence of skin irritation in humans: "Dermal application of dioctyl phthalate (details of the isomer unknown) produced skin irritation and sensitization in human volunteers." These inconsistent results do not allow the presence or absence of skin irritation to be determined, and thus classification is not possible.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available An epidemiological study reports that occupational exposure to phthalic acids (including di-n-octyl phthalate in the gaseous form) showed irritation of the eye and upper respiratory tract (CERI Hazard Data 2001-63 (2002)).
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		No data available. An epidemiological study provides evidence of respiratory sensitization in humans (CERI Hazard Data 2001-63 (2002)): "workers occupationally exposed to dioctyl phthalate (structural details unknown) exhibited asthmatic responses."
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the description in the report on epidemiological studies of human exposure (MOE Risk Assessment vol. 4 (2005)): "Dermal application of dioctyl phthalate (details of the isomer missing) produced skin irritation and sensitization in human volunteers."
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and no positive data on mutagenicity tests in vitro (several indices), described in CERI Hazard Data 2001-63 (2002), ATSDR (1997) and NTP DB (Access on April 2006).
6 Carcinogenicity Classification not possible - - - - Classification not possible based on expert judgment in the absence of existing classification, though CERI Hazard Data 2001-63 (2002) provides some toxicity data.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of decreased number of live borns at doses at which parental toxicity is unknown in mouse teratogenicity studies, described in MOE Risk Assessment vol. 4 (2005) and ATSDR (1997).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Insufficient data available CERI Hazard Data 2001-63 (2002) provides evidence of acute effects of di-n-octyl phthalate in humans: "workers occupationally exposed to dioctyl phthalate (structural details unknown) exhibited asthmatic responses."
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Since it was suggested from 96-hour LC50>20mg/L of the fish (Oryzias Latipest) (MOE Eco-Toxicity Tests of Chemicals, 1997) that relevant toxicity is not indicated in the water solubility (0.022mg/L(PHYSPROP Database, 2005)) of this substance, it was classified into Not classified.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Although it is water-insolubility and acute toxicity was not reported within the aqueous solubility concentrations and there was the bio-accumulation (log Kow=8.1(PHYSPROP Database, 2005)), since there was the rapidly degrading (the decomposition by BOD: 67% (Existing Chemical Safety Inspections Data)), it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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