Chemical Name:Piperazine
CAS:110-85-0
ID: | 469 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Not classified | - | - | - | - | Classified as flammable according to ICSC (2003). Classified into Class 8 (UN#2579) (UN Recommendations on the Transport of Dangerous Goods). |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 320degC (ICSC, 2003). |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available (melting point: 106degC (ICSC, 2003), test temperature: 140degC). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine and chlorine |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the LD50 value of 1,280mg/kg calculated from the testing data of rat LD50 (oral route) of 600mg/kg, 11,200mg/kg (CERI Hazard Data 2001-13 (2002)), 2,830mg/kg (CERI-NITE Hazard Assessment No.19 (2005)), 2,600mg/kg (EU-RAR No.56 (2005)), 2,050mg/kg, 3,000mg/kg (PATTY (4th, 2000)) and 1,900mg/kg (DFGOT vol.9 (1998)). | |
1 | Acute toxicity (Dermal) | Category 4 | Warning | H312: Harmful in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on the rabbit LD50 (dermal route) value of 1,590mg/kg representing the lower of the two testing data, 4,000mg/kg (CERI Hazard Data 2001-13 (2002)) and 1,590mg/kg (CERI-NITE Hazard Assessment No.19 (2005)). | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Category 1A-1C | Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the description in the report on rabbit skin irritation tests (4 hour application) (CERI-NITE Hazard Assessment No.19 (2005), EU-RAR No.56 (2005) and DFGOT vol.9 (1998)): Severe irritation with irreversible effects, indicative of corrosivity. Although classified as Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed. | |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 2001-13 (2002), CERI-NITE Hazard Assessment No.19 (2005), PATTY (4th, 2000) and DFGOT vol.9 (1998)): "strong irritation," "severe corneal opacity" and "serious eye damage which is unlikely to heal." The substance is thus considered to possess a potential for corrosivity. | |
4 | Respiratory sensitization | Category 1 | Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
Based on the description of the human health effects (CERI Hazard Data 2001-13 (2002), EU-RAR No.56 (2005) and PATTY (4th, 2000)): Piperazine induced symptoms of respiratory sensitization such as asthma. Also due to the fact that the substance is classified as a "Respiratory Sensitizing Substance" by the Japanese Society of Occupational Allergy. | |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on the descriptions of the human health effects (CERI Hazard Data 2001-13 (2002), EU-RAR No.56 (2005), CERI-NITE Hazard Assessment No.19 (2005) and PATTY (4th, 2000)): the substance showed "positive" in patch tests. Also due to the fact that the substance is classified as a "Skin Sensitizing Substance" by the Japanese Society of Occupational Allergy. | |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and no positive data on mutagenicity tests in vitro (several indices), described in CERI-NITE Hazard Assessment No.19 (2005), NITE Initial Risk Assessment No.19 (2005) and NTP DB (Access on March 2006). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible based on expert judgment in the absence of existing classification. |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | Insufficient data available |
8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system, respiratory system) | Warning | H371: May cause damage to organs (nervous system, respiratory system) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence including "somnolency, nausea or vomiting" (RTECS (2004)), "corrosive to the eye, skin and respiratory tract; adversely affects the nervous system; ingestion of large doses may cause functional impairment of the organs involved and can result in loss of consciousness" (ICSC (J) (2003)). | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, respiratory system) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (nervous system, respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence including "headache , nausea, vomiting, diarrhea, lethargy, tremor, incoordination and muscle weakness" (CERI Hazard Data 2001-13 (2002)), and "chronic bronchitis" (CERI-NITE Hazard Assessment No.19 (2005)). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 48 hours EC50=21mg/L of the crustacea (Daphnia magna) (EU-RAR, 2004). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Although the acute toxicity was Category 3, judging from the NOEC=12.5mg/L during 21 days of the crustacea (Daphnia magna) (EU-RAR, 2004), it was classified into Not classified. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |