GHS Classification Result

Chemical Name：2-Vinylpyridine
CAS：100-69-6

Result：
ID: 467
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flash point is 42degC (ICSC (2000)), which is classified into Category 3. Those containing stabilizers are classified into Class 3, Division 6.1 and Class 8 (UN#3073) (UN Recommendations on the Transport of Dangerous Goods).
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though containing unsaturated bonds. Those containing stabilizers are classified into Class 3, Division 6.1 and Class 8 (UN#3073) (UN Recommendations on the Transport of Dangerous Goods).
9 Pyrophoric liquids Classification not possible - - - - No data available. Those containing stabilizers are classified into Class 3, Division 6.1 and Class 8 (UN#3073) (UN Recommendations on the Transport of Dangerous Goods).
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available. Those containing stabilizers are classified into Class 3, Division 6.1 and Class 8 (UN#3073) (UN Recommendations on the Transport of Dangerous Goods).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 100mg/kg calculated from the testing data of rat LD50 (oral route) of 336mg/kg (CERI-NITE Hazard Assessment No.18 (2005)), 951mg/kg (CERI-NITE Hazard Assessment No.18 (2005)), 100mg/kg (MOE Risk Assessment vol. 4 (2005)) and 200mg/kg (PATTY (4th, 2000)).
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the guinea pig LD50 (dermal route) value of 160mg/kg representing the lower of the two testing data, 160mg/kg (CERI-NITE Hazard Assessment No.18 (2005)) and 300mg/kg (PATTY (4th, 2000)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the evidence of "severe irritation" from guinea pig skin irritation test (24 hour application) (CERI-NITE Hazard Assessment No.18 (2005)). Also based on the description in the report on human health effects (CERI Hazard Data 2000 - 40 (2001), CERI-NITE Hazard Assessment No.18 (2005) and PATTY (4th, 2000)): "Accidental skin contact causes burning pain, and even if the skin is immediately washed, quite severe dermatitis occurs. At the site of inflammation, reddish brown coloration subsequently develops, which takes about a month to disappear."
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on eye irritation tests in rabbits and guinea pigs (CERI-NITE Hazard Assessment No.18 (2005) and PATTY (4th, 2000)): "severely irritating."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the positive results in guinea pig skin sensitization tests (CERI-NITE Hazard Assessment No.18 (2005) and PATTY (4th, 2000)) and the evidence of sensitization in humans reported in CERI Hazard Data 2000-40 (2001), CERI-NITE Hazard Assessment No.18 (2005), MOE Risk Assessment vol. 4 (2005) and PATTY (4th, 2000).
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and no positive data on mutagenicity tests in vitro (several indices), described in CERI-NITE Hazard Assessment No.18 (2005), NITE Initial Risk Assessment No.18 (2005) and NTP DB (Access on March 2006).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - The results of repeated dose toxicity studies in rats suggest changes in reproductive organ weight (MOE Risk Assessment vol. 3 (2004)). However, these findings are toxicologically insignificant and no data on reproductive toxicity are available as a reliable basis for classification.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "temporary mild irritation of the eye, nose and pharynx, headaches, vomiting, hypersensitivity and loss of appetite" (CERI Hazard Data 2000-40 (2001)), and the evidence from animal studies including "aggressiveness, reduced locomotor activity, labored respiration, spasm and lethargy" (NITE Initial Risk Assessment No.18 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Categories 1 and 2.
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system, respiratory system) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "salivation, debility, reduced activity, tremor and spasm" (MOE Risk Assessment vol. 4 (2005)), "salivation and pulmonary congestion" (HSDB (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96 hours LC50=6.5mg/L of the fish (Oryzias Latipest) (MOE eco-toxicity tests of chemicals (2001) and others.).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 2 and the bio-accumulation potential was low (log Kow=1.54(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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