GHS Classification Result

Chemical Name：Nonylphenol
CAS：25154-52-3

Result：
ID: 459
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - The flash point is 140degC (c.c.) (ICSC (2003))
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures (flash point: 370degC (ICSC, 2003)).
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen, with the oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 851mg/kg calculated from the testing data of rat LD50 (oral route) of 1,300mg/kg, 2,462mg/kg (CERI-NITE Hazard Assessment No.1 (2004)), 580mg/kg and 1,620mg/kg (CERI Hazard Data 96-44 (1998)).
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LD50 (dermal route) value of 2,031mg/kg representing the lower of the two fixed values of the testing data, 2,140mg/kg (CERI Hazard Data 96-44 (1998)), >2,000mg/kg (CERI-NITE Hazard Assessment No.1 (2004)) and 2,031mg/kg (EU-RAR No.10 (2002)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on rabbit skin irritation tests (CERI-NITE Hazard Assessment No.1 (2004)): "Prolonged exposure to nonylphenol produces corrosive effects on the skin." Also based on the description in EU-RAR No.10 (2002): "Based on the results obtained in two studies, it is reasonable to consider nonylphenol to be corrosive on contact with skin." Although classified into Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in CERI-NITE Hazard Assessment No.1 (2004): "Causes moderate to severe eye irritation." Also based on the description in EU-RAR No.10 (2002): "Nonylphenol is severely irritating to the eye, inducing corneal opacities which do not fully clear up during the 21-day observation period." These results indicate that nonylphenol is a "severe eye irritant."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on the description in CERI-NITE Hazard Assessment No.1 (2004): "Guinea pig Maximization tests show no indication of sensitization." Also based on the description in EU-RAR No.10 (2002): "The results of several guinea pig Maximization tests suggest that nonylphenol does not have skin sensitizing potential."
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in EU-RAR No.10 (2002).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of adverse effects on pups (including suppressed body weight gain, reduced food consumption and increased uterus weight) observed at non-maternally toxic doses in rat reproductive toxicity studies and 3-generation reproductive toxicity studies, described in CERI-NITE Hazard Assessment No.1 (2004).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "renal tubular epithelial degeneration and renal tubular dilatation" (CERI-NITE Hazard Assessment No.1 (2004)). The effects were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours EC50=0.0127mg/L of the crustacea (Amphipod) (CERI/NITE Hazard Assessment Report, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (BCF=330(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information