GHS Classification Result

Chemical Name：p-Nnitrophenol
CAS：100-02-7

Result：
ID: 458
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Because of a lack of data, though the substance contains nitro groups with its oxygen budget calculated at -132 and a rapid decomposition increases pressure, according Bretherick (J) (5th,1998). Classified into Division 6.1 (UN#1663 Nitrophenol) (UN Recommendations on the Transport of Dangerous Goods).
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Insufficient data available, though classified flammable and the powder or granules, when mixed with the air, may cause dust explosion (ICSC (2004)). Classified into Division 6.1 (UN#1663 Nitrophenol) (UN Recommendations on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not classified - - - - No data available, though containing nitro groups. Classified into Division 6.1 (UN#3441 Chlorodinitrobenzene (solid)) (UN Recommendations on the Transport of Dangerous Goods).
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 490degC (ICSC, 2004)).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 111 - 116degC (ICSC, 2004), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being organic compounds containing oxygen bonding elements other than carbon and hydrogen. Classified into Division 6.1 (UN#1663 Nitrophenol) (UN Recommendations on the Transport of Dangerous Goods).
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 109mg/kg calculated from the testing data of rat LD50 (oral route) of 50mg/kg, 620mg/kg (CERI Hazard Data 2001-65 (2002)), 202mg/kg (MOE Risk Assessment vol.4 (2005)), 220mg/kg (CICAD 20 (2000)) and 230mg/kg (ATSDR (1992)).
1 Acute toxicity （Dermal） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on guinea pig skin irritation tests (though the results are not those of 4 hour application) (CERI Hazard Data 2001-65 (2002)): "Eschar, severe scarring," "inflammation, edema, yellow-brown pigmentation, dermal swelling and severe crust formation" indicative of strong irritancy. Although classified into Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 2001-65 (2002) and ATSDR (1992)): "Iris congestion, lens opacity, puruloid effusion," "moderate to severe corneal opacity, bullous tissues of the conjunctiva and neovascularization in the cornea" indicative of corrosivity.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the evidence of "moderate sensitization" from guinea pig skin sensitization tests (CERI Hazard Data 2001-65 (2002) and CICAD 20 (2000)). Also based on the description in the report on epidemiological studies of human exposure (CERI Hazard Data 2001-65 (2002), MOE Risk Assessment vol. 4 (2005) and CICAD 20 (2000)): "Evidence of skin sensitization in humans has been reported."
5 Germ cell mutagenicity Not classified - - - - Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on germ cell mutagenicity tests in vivo and somatic cell mutagenicity tests in vivo, described in ATSDR (1992), CICAD 20 (2000) and NTP TR417 (1993).
6 Carcinogenicity Classification not possible - - - - Classification not possible based on expert judgment in the absence of existing classification, though NTP TR417 (1993), CERI Hazard Data 2001-65 (2002), ATSDR (1992) and CICAD 20 (2000) provide hazard data (carcinogenicity studies in mice and Syrian hamsters)
7 Reproductive toxicity Not classified - - - - Based on no evidence of treatment-related adverse effects on reproduction/development observed in 2-generation reproductive toxicity studies and developmental toxicity/teratogenicity studies, described in CERI Hazard Data 2001-65 (2002), CICAD 20 (2000) and ATSDR (1992). Although CICAD suggests some evidence of adverse effects on pups referring to the teratogenicity study conducted by Kavlock, when conducting this classification, the descriptions in CERI Hazard Data and ATSDR (no effects on pups) were used as a basis for evaluation.
8 Specific target organ toxicity - Single exposure Category 1 (blood system) Danger H370: Causes damage to organs (blood system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "headaches, drowsiness, nausea, and respiratory depression with blue color to the lips, ears, and fingernails (cyanosis) indicative of methemoglobinemia" (NTP TR417 (1993)).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system), Category 2 (liver) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (blood system)
H373: May cause damage to organs through prolonged or repeated exposure (liver) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "fatty degeneration of the liver" (CICAD 20 (2000)), "elevated methemoglobin levels in all treated groups" (CICAD 20 (2000)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (blood system) and Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96 hours LC50=2.2mg/L of the fish (Rainbow Trout) (ECETOC TR91, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Although acute toxicity was Category 2, it was classified into Not classified from 30 days NOEC=1200microg/L(the fish (Rainbow Trout)) (MOE Risk Assessment vol. 3 (2004))


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information