GHS Classification Result

Chemical Name：2,2,2-trichloro-1,1-bis(4-chlorophenyl)ethanol
CAS：115-32-2

Result：
ID: 444
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data, though classified as flammable according to ICSC (2003)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat (up to 150degC) (Agricultural Chemical Registration Data)
11 Self-heating substances and mixtures Not classified - - - - Stable to heat (up to 150degC) (Agricultural Chemical Registration Data)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine and oxygen (but not fluorine), with the chlorine and oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with melting point of >55degC are not available (melting point:72.4degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 578mg/kg (Agricultural Chemical Registration Data (2005)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rat LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (2005)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Based on the rat LC50 (inhalation route) value of >5.0mg/L (4 hours), together with the absence of mortality (Agricultural Chemical Registration Data (2005)).
2 Skin corrosion/irritation Not classified - - - - Based on the evidence of only mild irritation with the maximum Draize score of 0.8, which cleared up on day 3, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (2005)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the evidence of irritant effects on the cornea, iris and conjunctiva, which persisted for at least 21 days of observation (Agricultural Chemical Registration Data (2005)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on positive results in guinea pig skin sensitization tests employing the Buehler method (Agricultural Chemical Registration Data (1993)).
5 Germ cell mutagenicity Not classified - - - - Based on negative data in in vitro reverse mutation tests and rat in vivo chromosome aberration tests (Agricultural Chemical Registration Data (2005)).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category C by IARC (1987).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on reproduction or offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (2005)).
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "inanimation," "ataxia," "collapse," "lacrimation," and "salivation" (Agricultural Chemical Registration Data (2005)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Category 1 (thyroid), Category 2 (liver, kidney, adrenal gland) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (thyroid)
H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, adrenal gland) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "increased incidence of hypertrophy of the thyroid follicular epithelium," "hepatocellular hypertrophy, hepatocellular necrosis/vacuolization," "reduced kidney weight and centrilobular hepatocellular hypertrophy, and dilatation/degeneration of the renal cortical tubules," and "hypertrophy of the adrenal cortical cells" (Agricultural Chemical Registration Data (2005)). These effects were observed at dosing levels within the guidance value ranges for Category 1 (thyroid gland) and Category 2 (liver, kidneys, adrenal).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours EC50=0.096mg/L of the crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 1998).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since the acute toxicity was Category 1 and it had no rapidly degrading (the decomposition by BOD: 0% (Existing Chemical Safety Inspections Data)), and it had the bio-accumulation (BCF=10000 (Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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