GHS Classification Result

Chemical Name：2,4,6-Trichloro-1,3,5-triazine
CAS：108-77-0

Result：
ID: 442
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC, 2004)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-flammable (ICSC, 2004)
11 Self-heating substances and mixtures Not classified - - - - Non-flammable (ICSC, 2004)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 275mg/kg calculated from the testing data of rat LD50 (oral route) of 1,143mg/kg, 315mg/kg, 327mg/kg, 930mg/kg and 208mg/kg (SIDS (2005)).
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LD50 (dermal route) value of 5,000mg/kg (SIDS (2005)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LC50 value of 0.0911mg/L calculated from the testing data of rat LC50 (inhalation of dust) of 0.17mg/L (SIDS (2005)), 0.086mg/L (SIDS (2005)) and 0.201mg/L (SIDS(2005)).
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description of rabbit skin irritation tests (4 hour application) (CERI Hazard Data 2000-55 (2001) and SIDS (2005)): "irritating to the skin," though the severity of the effects is unknown. Although classified into Category 2-3, the substance should be placed in Category 2 from the viewpoint of safety.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the data on rabbit eye irritation tests (CERI Hazard Data 2000-55 (2001) and (SIDS (2005)) and human health effects (CERI Hazard Data 2000-55 (2001)): "severely irritating." Although classified into Category 1-2A, the substance should be placed in Category 1 from the viewpoint of safety.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the description in the report on skin sensitization studies in animals (CERI Hazard Data 2000-55 (2001) and SIDS (2005)): "skin sensitization: positive."
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in SIDS (2005) and CERI Hazard Data 2000-55 (2001).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of a slight increase in postimplantation loss at doses causing parental toxicity in rat teratogenicity studies, described in MOE Risk Assessment vol. 3 (2004).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, nervous system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (respiratory system, nervous system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence including "the occurrence of pulmonary edema 2-3 hours after inhalation of vapour or fume," "purulent bronchitis" (MOE Risk Assessment vol. 3 (2004)), and the evidence from animal studies including "hypokinesis, lethargy, hypomyotonia, loss of reflex, cyanosis, gait disorder, reduced reflex, swelling and edema in the lung with secretion of mucus, and hydropneumothorax" (SIDS (2001)).The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, liver, spleen, blood system, kidney, heart) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, liver, spleen, blood system, kidney, heart) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "irritation of the upper and lower respiratory tracts, occurrence of bronchitis and bronchial pneumonia" (MOE Risk Assessment vol. 3 (2004)), and the evidence from animal studies including "histological changes in the liver/spleen/lung, decreased RBC/hemoglobin/hematocrit levels," "reduced RBC, decreased hemoglobin levels, interstitial pneumonia, degeneration of the liver/kidneys/myocardium, and bronchial pneumonia in a fatal case" (CERI Hazard Data 2000-55 (2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It was classified into Not classified from 24 hours EC50>1000mg/L (the crustacea (Daphnia magna)) of cyanuric ester(hydrolysis product of this product) (SIDS (2005) and others.).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it was not water-insolubility (the water-solubility =400.8mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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