Chemical Name：1,3,5,7-Tetraazatricyclo[3.3.1.13.7]decane; Hexamethylenetetramine
CAS：100-97-0

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
6	Flammable liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
7	Flammable solids	Category 2		Warning	H228: Flammable solids	P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P280: Wear protective gloves/protective clothing/eye protection/face protection.	The substance is classified as flammable, and its powder or granules, when mixed with the air, may cause dust explosion according to ICSC (2004). Classified into Division 4.1 and Packing Group III (UN#1328) (UN Recommendations on the Transport of Dangerous Goods).
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Containing no chemical groups with explosive or self-reactive properties
9	Pyrophoric liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
10	Pyrophoric solids	Not classified	-	-	-	-	Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 390degC (ICSC, 2004).
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Classified into Division 4.1 (UN#1328) (UN Recommendations on the Transport of Dangerous Goods)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
14	Oxidizing solids	Not applicable	-	-	-	-	Organic compounds containing no oxygen, fluorine and chlorine
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available, though the substance acts on aluminum, according to ICSC (2004).

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 (oral route) value of 9,200mg/kg (DFGOT vol.5 (1993)).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	Based on the description of the human health effects (CERI Hazard Data 96-38 (1997), MOE Risk Assessment vol. 4 (2004) and DFGOT vol.5 (1993)): "The substance slightly irritates the skin," though the results of 4 hour patch tests in rabbits suggest no evidence of irritation (DFGOT vol.5 (1993)).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Based on the description of the human health effects (MOE Risk Assessment vol. 4 (2004) and DFGOT vol.5 (1993)): "The substance slightly irritates the eye," though the results of rabbit eye irritation tests suggest no irritation (DFGOT vol.5 (1993)).
4	Respiratory sensitization	Category 1		Danger	H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled	P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ...	Based on the description in the report on epidemiological studies (MOE Risk Assessment vol. 4 (2004) and DFGOT vol.5 (1993)): "Asthma-like symptoms were observed." Also based on the description in MOE Risk Assessment vol. 4 (2004): "Attacks of asthma brought on." The substance is thus considered to possess a potential for respiratory sensitization.
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Based on the positive results in guinea pig Maximization Tests (DFGOT vol.5 (1993)) and epidemiological evidence of skin sensitization (CERI Hazard Data 96-38 (1997), MOE Risk Assessment vol. 4 (2004) and DFGOT vol.5 (1993)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data on multi-generation mutagenicity tests (dominant lethal tests) and somatic cell mutagenicity tests in vivo (chromosome aberration tests), and the absence of data on germ cell mutagenicity tests in vivo, described in PATTY (4th, 2000) and DFGOT vol.5 (1993).
6	Carcinogenicity	Classification not possible	-	-	-	-	Classification not possible based on expert judgment in the absence of existing classification, though CERI Hazard Data 96-38 (1997), PATTY (4th, 2000) and DFGOT vol.5 (1993) provide some toxicity data.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence of slight increases in the number of pups stillborn or dying in early infancy though no treatment effects on body weights of parental animals were observed (no data on other endpoints are available) in teratogenicity studies with dogs, described in MOE Risk Assessment vol. 3 (2004), PATTY (4th, 2000) and DFGOT vol.5 (1993).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system, kidney)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the human evidence: "acute symptoms including respiratory depression and chest tightness" (MOE Risk Assessment vol. 2 (2003)), "cystitis, proteinuria, hematuria," "inflammation of renal tubules and renal pelvis" (CERI Hazard Data 96-38 (1997)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available