GHS Classification Result

Chemical Name:O-3,5,6-trichloro-2-pyridyl O,O-dimethyl phosphorothioate
CAS:5598-13-0

Result:
ID: 432
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat (up to 150degC) (Agricultural Chemical Registration Data)
11 Self-heating substances and mixtures Not classified - - - - Stable to heat (up to 150degC) (Agricultural Chemical Registration Data)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 2.64mg/L (20degC) (Agricultural Chemical Registration Data))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Cannot be classified though being organic compounds containing oxygen bound to elements other than carbon and hydrogen
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data on the substances with melting points of <55degC (melting point: 46degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 1,828mg/kg (Agricultural Chemical Registration Data (1989)).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (1989)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification cannot be determined, though the available rat inhalation studies reported the LC50 values of >0.031mg/L and >0.67mg/L (Agricultural Chemical Registration Data (1989, 2005)).
2 Skin corrosion/irritation Not classified - - - - In rabbit skin irritation tests, the treated animals exhibited the highest Draize score of 0.7 and were fully recovered after 24 hours (Agricultural Chemical Registration Data (1989)).
3 Serious eye damage/eye irritation Not classified - - - - In the available rabbit eye irritation tests, mild effects were noted immediately after instillation, but the effects cleared up by 24 hours (Agricultural Chemical Registration Data (1989)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - No skin sensitizing potential was found in guinea pig sensitization tests (Agricultural Chemical Registration Data (1989)).
5 Germ cell mutagenicity Not classified - - - - Based on negative data in in vitro chromosome aberration tests, in vitro reverse mutation tests and mouse in vivo micronucleus tests (Agricultural Chemical Registration Data (1989)).
6 Carcinogenicity Not classified - - - - There was no treatment-related increase in tumor incidence observed in 2-year (rats) and 18-month (mice) carcinogenicity studies (Agricultural Chemical Registration Data (1989, 1991)).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on parental reproduction and offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1989)).
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including "piloerection," "tremors," "perspiration," "lacrimation," and "diarrhea" (Agricultural Chemical Registration Data (1973)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In repeat dose toxicity studies in animals, increased organ weights and cholinesterase inhibition were noted, but no target organs were identified from these findings (Agricultural Chemical Registration Data (1991)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48 hours EC50=0.62microg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 1992).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=4.31 (PHYSPROP Database, 2005)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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