GHS Classification Result

Chemical Name：Dioxins
CAS：

Result：
ID: 430
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition (2,3,7,8-tetrachlorodibenzo-p-dioxin)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition (2,3,7,8-tetrachlorodibenzo-p-dioxin)
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition (2,3,7,8-tetrachlorodibenzo-p-dioxin)
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition (2,3,7,8-tetrachlorodibenzo-p-dioxin)
7 Flammable solids Not classified - - - - Classified into Division 6.1 (UN#2811 (ICSC (2004)), toxic, solid, organic, n.o.s.) (UN Recommendation on the Transport of Dangerous Goods)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition (2,3,7,8-tetrachlorodibenzo-p-dioxin)
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#2811 (ICSC (2004)), toxic, solid, organic, n.o.s.) (UN Recommendation on the Transport of Dangerous Goods)
11 Self-heating substances and mixtures Not classified - - - - Classified into Division 6.1 (UN#2811 (ICSC (2004)), toxic, solid, organic, n.o.s.) (UN Recommendation on the Transport of Dangerous Goods)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition (2,3,7,8-tetrachlorodibenzo-p-dioxin)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine and oxygen (but not fluorine), with the chlorine and oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 305-306degC, 2,3,7,8-tetrachlorodibenzo-p-dioxin, ICSC (2004)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 1 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 0.022mg/kg representing the lower of the two testing data, 0.022mg/kg and 0.045mg/kg (PATTY (4th, 1999)) (tetrachlorodibenzodioxin). Based on the LD50 value of 0.013mg/kg calculated from the testing data of rat LD50 (oral route) of 0.022mg/kg, 0.013mg/kg, 0.043mg/kg and 0.34mg/kg (IARC 69 (1997)) (2,3,7,8-tetrachlorodibenzodioxin).
1 Acute toxicity （Dermal） Category 1 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 (dermal route) value of 0.275mg/kg (PATTY (4th,1999)) (tetrachlorodibenzodioxin).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Classification not possible - - - - Classification not possible due to the insufficiency of data. As the human health effects (though not local toxic effects on the eye) of 2,3,3',4,4'-pentachlorobiphenyl, "most patients showed eye discharge and other severe ocular effects during the acute phase of the Yusho and Yu-Cheng syndrome. These effects include meibomian gland changes (enlargement, inflammation, hypersecretion of cheese-like material) and dark-colored pigmentation of the conjunctivae and eyelids."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in ATSDR (1998), NTP DB (Access on August 2006), EHC 88 (1989) and IARC 69 (1997).
6 Carcinogenicity Classification not possible - - - - Classification not possible based on expert judgment since existing classification is available only for individual compounds of dioxins and not for "dioxins" as a whole. 2,3,7,8-Tetrachlorodibenzodioxin (CAS 1746-01-6) is classified as Category 1 (Group 1 by IARC (1997) and Category K by NTP (2005)), 1,2,3,7,8-pentachlorodibenzodioxin (CAS 40321-76-4) is "Not classified" (Category 3 by IARC (1997)), 1,2,3,6,7,8-hexachlorodibenzodioxin (CAS 57653-85-7) is classified as Category 2 (Category 3 by IARC (1997) and Category B2 by EPA (1991)), and 1,2,3,7,8,9-hexachlorodibenzodioxin (CAS 19408-74-3) is "Not classified" (Category 3 by IARC (1997) and Category B2 by EPA (1991)).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of cleft palate in the pups at non-parentally toxic doses in mouse teratogenicity studies, described in EHC 88 (1989), ATSDR (1998) and IARC 15 (1977).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, nervous system, cardiovascular system, skin, skin appendage, liver, urinary bladder, kidney, adrenal gland, gastrointestinal tract, testis, blood system, thymus, visual organs, bone marrow) Danger H370: Causes damage to organs (respiratory system, nervous system, cardiovascular system, skin, skin appendage, liver, urinary bladder, kidney, adrenal gland, gastrointestinal tract, testis, blood system, thymus, visual organs, bone marrow) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "bronchitis and laryngitis, hemorrhagic pneumonia, peripheral neuropathy, chloracne" (ATSDR (1998)), "cardiomyopathy" (EHC 88 (1989)), and the evidence from animal studies including "epithelial hyperplasia in the renal pelvis, inflamed eyelids, facial hair loss with acneform lesions, moderate to severe ileitis characterized by hyperplasia of the mucosal epithelium with hemorrhaging and necrosis," (ATSDR (1998)), "adrenal hemorrhages and moderate atrophy of the zona glomerulosa were seen; changes in the spermatogenic epithelium were observed; central congestion with occasional degeneration of hepatocytes; hemolysis and hyperproteinemia were found; retro-orbital hemorrhages with exophthalmus and hemorrhages with detachment of the retina were seen; bone marrow atrophy, hyperplasia of the renal pelvis extending into the ureter and involving the urinary bladder mucosa; loss of toe and finger nails; hyperkeratosis of the skin; atrophy of the thymus with reduced lymphocyte counts." (EHC 88 (1989)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (skin, liver, urinary bladder, visual organs, nervous system, auditory organ, respiratory system, blood system, gastrointestinal tract, kidney, thyroid, thymus, ovaria, bone marrow, adrenal gland, pancreas, cardiovascular system, spleen) Danger H372: Cause damage to organs through prolonged or repeated exposure (skin, liver, urinary bladder, visual organs, nervous system, auditory organ, respiratory system, blood system, gastrointestinal tract, kidney, thyroid, thymus, ovaria, bone marrow, adrenal gland, pancreas, cardiovascular system, spleen) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "chloracne and neurological symptoms; liver biopsies revealed mild steatosis, periportal fibrosis; hemorrhagic cystitis and focal pyelonephritis" (ATSDR 1998), "ocular manifestations, numbness of the limbs, feeling of weakness, muscular spasms, hearing difficulties, and a persistent bronchitis" (EHC 88 (1989)), and the evidence from animal studies including "anemia, leukopenia, atrophy of ovary, hypocellularity of the bone marrow, liver necrosis, bile duct hyperplasia and edema, atrophy of spleen and thymus, and gastrointestinal hemorrhages" (EHC 88 (1998)), "adrenal cortic atrophy/hyperplasia, cardiomyopathy, mesenteric arteritis, nephropathy, hyperplasia of thyroid gland follicular cells; persistent inflammation of the pancreas" (NTP TR 521 (2006)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 72 hours LC50=0.0135microg/L(the fish (Oryzias latipes)) of 2,3,7,8-tetrachlorodibenzodioxin was 0.0135microg/L (AQUIRE (2003)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and there was no rapidly degrading (the half life is 550-590 days in the water including bottom material (EHC88 (1989))), and there was the bio-accumulation (BCF=86000(rainbow trout) (AQUIRE (2003))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations

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