GHS Classification Result

Chemical Name：3,5-diiodo-4-octanoyloxybenzonitrile
CAS：3861-47-0

Result：
ID: 424
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Classification not possible - - - - Classification not possible due to lack of data
11 Self-heating substances and mixtures Classification not possible - - - - Classification not possible due to lack of data
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with melting point of >55degC are not available (melting point:56.6degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 385mg/kg (Agricultural Chemical Registration Data (1990)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (2001)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification cannot be determined, though the available rat dermal study reported the LC50 value of >2.4mg/L (Agricultural Chemical Registration Data (1990)).
2 Skin corrosion/irritation Not classified - - - - Based on the evidence of slight effects with the maximum Draize score of ca. 1.0, which were fully recovered within 4 days, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (2001)). The substance is thus considered non-irritating.
3 Serious eye damage/eye irritation Not classified - - - - Based on the evidence of slight effects with the maximum Draize score of ca. 1.0, which resolved within 24 hours, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1990)). The substance is thus considered non-irritating.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on positive results in guinea pig skin sensitization tests employing the Maximization method (Agricultural Chemical Registration Data (2004)).
5 Germ cell mutagenicity Not classified - - - - Based on negative data in in vitro studies (reverse mutation tests and mouse lymphoma tests) and mouse in vivo micronucleus tests (Agricultural Chemical Registration Data (1990, 2003)).
6 Carcinogenicity Not classified - - - - There was no treatment-related increase in tumor incidence observed in 2-year (rats) and 18-month (mice) carcinogenicity studies (Agricultural Chemical Registration Data (1992)).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on parental reproduction and offspring development observed in mouse 2-generation reproduction studies and rabbit teratogenicity studies (Agricultural Chemical Registration Data (1990)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In single dose toxicity studies in animals, signs and symptoms of toxicity including "sedation," "hyperventilation," "piloerection," "anemic eyeball," "salivation," and "nasal secretion" were observed (Agricultural Chemical Registration Data (1990)). However, classification is not possible since no target organs were identified from these findings and the doses at which these effects were observed are not given.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to the insufficiency of data.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours EC50=11ppb of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (BCF=212(Agricultural Chemical Registration Data, )), since there was no rapidly degrading (BIOWIN()), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information