Chemical Name:S-4-phenoxybutyl N,N-dimethylthiocarbamate
CAS:62850-32-2
ID: | 421 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Not classified | - | - | - | - | Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat (up to 150degC) (Agricultural Chemical Registration Data) |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Stable to heat (up to 150degC) (Agricultural Chemical Registration Data) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Classification not possible due to lack of data on the substances with melting points of <55degC (melting point: 39.5degC (Agricultural Chemical Registration Data)). |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the rat LD50 (oral route) value of 1,150mg/kg (Agricultural Chemical Registration Data (1985)). | |
1 | Acute toxicity (Dermal) | Category 5 | - | Warning | H313: May be harmful in contact with skin | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Based on the rat LD50 (dermal route) value of 2,075mg/kg (Agricultural Chemical Registration Data (1985)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | Classification cannot be determined, though the available rat dermal study reported the LC50 value of >1.79mg/L (Agricultural Chemical Registration Data (1985)). |
2 | Skin corrosion/irritation | Not classified | - | - | - | - | Based on no evidence of irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1985)). |
3 | Serious eye damage/eye irritation | Not classified | - | - | - | - | Based on no evidence of irritation observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1985)). |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Not classified | - | - | - | - | No skin sensitizing potential was found in guinea pig sensitization tests employing the Maximization method (Agricultural Chemical Registration Data (1985)). |
5 | Germ cell mutagenicity | Category 2 | Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on positive data in in vitro chromosome aberration tests (Agricultural Chemical Registration Data (1989)) and in vivo micronucleus tests on mouse red blood cells (Agricultural Chemical Registration Data (1994)), though in vitro reverse mutation tests showed negative (Agricultural Chemical Registration Data (1985)). | |
6 | Carcinogenicity | Not classified | - | - | - | - | There was no treatment-related increase in tumor incidence observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration Data (1985)). |
7 | Reproductive toxicity | Not classified | - | - | - | - | Based on no evidence of adverse effects on parental reproduction and offspring development observed in rat 3-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1985, 1988)). |
8 | Specific target organ toxicity - Single exposure | Category 2 (systemic toxicity) | Warning | H371: May cause damage to organs (systemic toxicity) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including " reduced locomotor activity," "ataxic gait," "insensitiveness to contact or to pain," "muscle weakness," "prone position," "lateral position," "reduced respiration rate," "lacrimation," and "dyspnea" (Agricultural Chemical Registration Data (1985)). No target organs were identified from these findings. These effects were observed at dosing levels within the guidance value ranges for Category 2. | |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "increased liver weights," and "thickening of inner membrane of intrahepatic portal vein branches" (Agricultural Chemical Registration Data (1985)). These effects were observed at dosing levels within the guidance value ranges for Category 2. | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 96 hours LC50=0.0903mg/L of the fish (Carp) (Agricultural Chemical Registration Data, 2004). | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=3.28(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |